解整合素-金属蛋白酶33、1-磷酸鞘氨醇水平与哮喘患者肺功能的关系及其意义  

Relationship between serum levels of ADAM33, S1P and pulmonary function in asthmatic patients

作　　者：刘德义[1] 马胜喜[1] 刘雨婷[1] De-yi Liu;Sheng-xi Ma;Yu-ting Liu(Department of Respiratory Medicine,Xinxiang Central Hospital,Xinxiang,Henan,453000,China)

机构地区：[1]新乡市中心医院呼吸内三科

出　　处：《中国现代医学杂志》2019年第21期100-103,共4页China Journal of Modern Medicine

摘　　要：目的探讨血清解整合素-金属蛋白酶33(ADAM33)、1-磷酸鞘氨醇(S1P)在哮喘患者中的变化及其意义。方法选取新乡市中心医院2015年1月2017年12月收治的120例急性发作期哮喘患者(哮喘组)和60例健康对象(对照组),检测两组研究对象血清中的ADAM33、S1P水平,并根据哮喘病情进行分层分析;分析血清中ADAM33、S1P水平与患者外周血嗜酸性粒细胞(EOS)、免疫球蛋白E(IgE)、第1秒用力呼气容积占预计值百分比(FEV1%)、呼气峰值流速占预计值百分比(PEF%)的关系。结果哮喘组的血清中ADAM33、S1P水平高于对照组,差异有统计学意义(P<0.05);重度哮喘组的血清中ADAM33、S1P水平高于轻-中度患者,差异有统计学意义(P<0.05);哮喘组的外周血EOS、IgE高于对照组,差异有统计学意义(P<0.05),哮喘组的FEV1%、PEF%低于对照组,差异有统计学意义(P<0.05);哮喘组的血清S1P与外周血EOS、IgE呈正相关(r=0.629和0.572,均P=0.000),哮喘组的血清S1P、ADAM33与FEV1%、PEF%呈负相关(r=-0.382、-0.411、-0.574和-0.494,均P=0.000)。结论急性发作哮喘患者血清S1P、ADAM33水平升高,与患者肺功能降低、哮喘发作程度有关。Objective To investigate the changes and significance of serum ADAM33 and S1P in asthma patients.Methods Selected 120 patients with acute asthma(asthma group)and 60 healthy subjects(control group)were enrolled in our hospital from January 2015 to December 2017.The levels of ADAM33 and S1P in the serum of the two groups were measured,and stratified analysis was performed according to the condition of asthma;the relationships between the levels of ADAM33,S1P in serum and EOS,IgE,FEV1%,PEF%of patients were analyzed.Results The levels of ADAM33 and S1P in the asthma group were higher than in the control group(P<0.05);the serum levels of ADAM33 and S1P in the severe asthma group were higher than those in the mild-to-moderate group(P<0.05);the levels of peripheral blood EOS and IgE in the asthma group were higher than those in the control group,and the difference between the two groups was statistically significant(P<0.05);the FEV1%and PEF%of the asthma group were lower than the control group(r=0.629 and 0.572,P=0.000);serum S1P and ADAM33 in the asthma group were negatively correlated with FEV1%and PEF%(r=-0.382,-0.411,-0.574 and-0.494,respectively,all P=0.000).Conclusions Serum levels of S1P and ADAM33 in patients with acute asthma increase,which is related to lung function and the degree of asthma attack.

关 键 词：哮喘 解整合素-金属蛋白酶33 1-磷酸鞘氨醇 

分 类 号：R562.2[医药卫生—呼吸系统]