消支助孕汤联合重组人干扰素α-2α栓治疗支原体感染不孕的临床有效性分析  

Analysis on the clinical effectiveness on mycoplasma infection-induced infertility treated with xiaozhizhuyun decoction and recombinant human interferon α-2α suppositor

作　　者：于晨芳[1] 石国亮[1] 于霞[1] 刘芳[1] 杨聘 YU Chen-fang;SHI Guo-liang;YU Xia;LIU Fang;YANG Pin(Hebei Hengshui No.4 People′s Hospital,Hengshui Hebei 053000)

机构地区：[1]河北省衡水市第四人民医院

出　　处：《世界中西医结合杂志》2019年第10期1427-1430,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研项目(2018547)

摘　　要：目的观察消支助孕汤口服联合重组人干扰素α-2α栓阴道外用治疗脾虚湿热蕴结型支原体感染性不孕患者的临床疗效。方法选取脾虚湿热蕴结型支原体感染性不孕患者180例,随机分为治疗组和对照组,治疗组采用消支助孕汤口服联合重组人干扰素α-2α栓阴道外用;对照组应用多西环素口服加重组人干扰素α-2α栓阴道外用。观察两组患者临床疗效、妊娠率、流产率及不良反应情况。结果两组治疗后中医证候积分与本组治疗前比较明显下降(P<0.05,P<0.01),差异有统计学意义;两组治疗后中医证候积分比较差异有统计学意义(P<0.01)。两组病例治疗后临床总有效率比较差异无统计学意义(P>0.05)。治疗组治疗后妊娠率与对照组比较,差异有统计学意义(P<0.01);两组治疗后流产率比较差异无统计学意义(P>0.05)。结论消支助孕汤联合重组人干扰素α-2α栓治疗脾虚湿热蕴结型支原体感染不孕,疗效显著,能有效缓解患者临床症状,提高妊娠率,降低流产率、减轻不良反应,疗效确切。Objective To observe the clinical effect on mycoplasma infection-induced infertility of spleen deficiency and interaction of damp and heat type treated with xiaozhizhuyun decoction and recombinant human interferonα-2αsuppositor.Methods A total of 180 patients with mycoplasma infection-induced infertility of spleen deficiency and interaction of damp and heat type were collected and randomized into a treatment group and a control group.In the treatment group,the combined treatment was provided with the oral administration of xiaozhizhuyun decoction and the vaginal external application of recombinant human interferonα-2αsuppositor.In the control group,the combined treatment was given with the oral administration of deoxytetracycline and the vaginal external application of recombinant human interferonα-2αsuppositor.The clinical effect,pregnancy rate,abortion rate and adverse reactions were observed in the two groups.Results After treatment,the TCM symptom scores were all reduced as compared with those before treatment in the same group(P<0.05,P<0.01),indicating the significant difference,and the difference was significant between the two groups(P<0.01).After treatment,the difference in the total effective rate was not significant statistically between the two groups(P>0.05).The pregnancy rate in the treatment group was different significantly as compared with the control group(P<0.01)and the difference in the abortion rate was not significant between the two groups(P>0.05).Conclusion The combined treatment with xiaozhizhuyun decoction and recombinant human interferonα-2αsuppositor achieves the significant effect on mycoplasma infection-induced infertility of spleen deficiency and interaction of damp and heat type.Such therapy effectively relieves the clinical symptoms,improves pregnancy rate,reduces abortion rate and alleviates adverse reactions in the patients.

关 键 词：不孕 支原体感染 消支助孕汤 重组人干扰素α-2α栓 

分 类 号：R711.6[医药卫生—妇产科学]