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作 者:陆聆韵 沈小珩[3] 袁民 LU Ling-yun;SHEN Xiao-hang;YUAN Min(Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Department of Traditional Chinese Medicine,North Hospital of Ruijin Hospital Affiliated to Shanghai Jiaotong University Medical College,Shanghai 201800;Department of Traditional Chinese Medicine,Ruijin Hospital Affiliated to Shanghai Jiaotong University Medical College,Shanghai 200025)
机构地区:[1]上海中医药大学,上海201203 [2]上海交通大学医学院附属瑞金医院北院中医内科,上海201800 [3]上海交通大学医学院附属瑞金医院中医科,上海200025
出 处:《世界中西医结合杂志》2019年第10期1460-1463,共4页World Journal of Integrated Traditional and Western Medicine
摘 要:目的探讨苍柴调中汤加味联合达英-35对多囊卵巢综合征的临床疗效。方法选取多囊卵巢综合征患者80例,随机数字表法分为对照组和观察组,每组40例。对照组给予达英-35治疗,观察组在对照组治疗的基础上给予苍柴调中汤加味治疗。观察两组治疗后临床疗效、促排卵情况、血清中性激素水平及炎性因子水平变化及不良反应发生情况。结果观察组治疗后临床总有效率高于对照组(P<0.05),观察组不良反应发生率明显低于对照组(P<0.05),差异具有统计学意义。与对照组比较,观察组血清中促黄体生成素(LH)、睾酮(T)及促卵泡素(FSH)、C反应白蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)含量水平明显降低(P<0.05),雌二醇(E2)含量升高(P<0.05),差异具有统计学意义。经过治疗,观察组排卵率明显高于对照组,妊娠率明显高于对照组(P<0.05),差异具有统计学意义。结论苍柴调中汤加味联合达英-35可有效改善多囊卵巢综合征患者性激素水平,抑制炎性反应,提高促排卵率,降低不良反应发生率,进一步提高其临床疗效。Objective To observe the clinical effect of polycystic ovary syndrome(PCOS)in the treament of Cangcha Tiaozhong Decoction combined with Daying-35.Methods Eighty patients with PCOS were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with Dayin-35,and the observation group was treated with Cangcha Tiaozhong decoction on the basis of the treatment of the control group.The clinical efficacy,ovulatory induction,serum sex hormone level,inflammatory factor leve and the adverse reactions were observed.Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group.The incidence of adverse reactions in the observation group(5%)was significantly lower than that in the control group(P<0.05).Compared with the control group,the levels of serum FSH,LH,T,CRP,IL-6,IL-6 and IL-8 in the observation group were significantly lower than those in the control group,and the levels of E2 in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the ovulatory rate of the observation group was significantly higher than that of the control group,and the pregnancy rate of the observation group was significantly higher than that of the control group(P<0.05).Conclusion Cangcha Tiaozhong decoction combined with Daying-35 can effectively improve the level of sex hormone,inhibit inflammatory reaction,increase ovulatory rate,reduce the incidence of adverse reactions and further improve the clinical efficacy in patients with PCOS.
分 类 号:R271.9[医药卫生—中西医结合] R711.75[医药卫生—中医妇科学]
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