经导管二尖瓣置换术治疗二尖瓣反流研究进展  

Transcatheter mitral valve replacement for mitral regurgitation: recent progress in research

作　　者：赵玉玺 鲍贤豪 曾照祥 吴明炜 李涛 艾尼瓦尔·艾克白尔 朱正龙 刘晓晨 冯家烜 周建 冯睿 景在平 ZHAO Yuxi;BAO Xianhao;ZENG Zhaoxiang;WU Mingwei;LI Tao;ANIWAER Aikebaier;ZHU Zhenglong;LIU Xiaochen;FENG Jiaxuan;ZHOU Jian;FENG Rui;JING Zaiping(Department of Vascular Surgery,Affiliated Changhai Hospital,Navy Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学附属长海医院血管外科

出　　处：《介入放射学杂志》2019年第10期1000-1004,共5页Journal of Interventional Radiology

基　　金：国家自然科学基金重点项目（81330034）;国家自然科学基金面上项目（81770476）;国家自然科学基金青年项目（81500369）

摘　　要：二尖瓣反流(MR)是最为常见的心脏瓣膜病,65岁以上人群中有明显(中/重度)MR患者较为常见。尽管外科手术治疗仍是明显MR患者金标准,但这些患者会因高风险拒绝或被认为不适合传统开放手术。随着经导管技术在主动脉瓣膜疾病中成熟应用,更多临床医师和制造商将目光投向人工二尖瓣经导管治疗MR。经导管二尖瓣置换术(TMVR)是一种微创手术,通过介入导管技术将人工心脏瓣膜输送至二尖瓣位置,从而完成人工瓣膜植入,恢复瓣膜功能。虽然TMVR面临诸多技术挑战,但随着对疾病深入了解和技术进步,这些挑战将会逐步克服。相关研究也正在积极推进。该文综述了正在开发的各种人工二尖瓣装置的技术特点以及在人体中初步试验结果。Mitral regurgitation(MR)is the most common cardiac valvular disease and significant(moderate/severe degree)MR is more commonly seen among people over the age of 65 years.Although surgical management,which is regarded as the gold standard of treatment,is still the first choice of treatment for patients with significant MR,these patients may refuse traditional open surgery because of high risk or these patients are considered to be unsuitable for traditional open surgery.With the mature application of transcatheter aortic valve replacement(TAVR)in treating aortic valve diseases,more clinicians and manufacturers turn their eyes to transcatheter treatment of MR with artificial mitral valve.Transcatheter mitral valve replacement(TMVR)is a minimally-invasive operation.Through delivering the artificial cardiac valve to the mitral valve site by interventional catheterization,the artificial mitral valve implantation is accomplished and the valvular function is recovered.Although TMVR faces a number of technical challenges,these challenges will be gradually overcome along with further understanding about MR and technological progress.Related researches are also being actively promoted.This paper aims to review the technical characteristics of various artificial mitral valve devices that are under development at present and to summarize the preliminary application results in human body.

关 键 词：二尖瓣反流 经导管二尖瓣置换术 治疗 进展 

分 类 号：R542[医药卫生—心血管疾病]