溃结2号方治疗脾虚湿盛型溃疡性结肠炎临床研究  

Clinical observation on Kuijie No.2 recipe in treating ulcerative colitis of spleen deficiency and dampness

作　　者：史英[1] 张铁 祝斌野 孙杰[1] 吴洁琼[1] 相祎[1] 刘金响 吴婷[1] 张莹[1] SHI Ying;ZHANG Tie;ZHU Binye(Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000)

机构地区：[1]陕西中医药大学第二附属医院脾胃病科,咸阳712000 [2]西安交通大学第一附属医院长安医院内四科,西安710118

出　　处：《陕西中医》2019年第11期1520-1522,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省中医药管理局科研项目(JCPT047)

摘　　要：目的:研究观察溃结2号方治疗脾虚湿盛型溃疡性结肠炎的临床疗效。方法:采用随机数字表法将72例脾虚湿盛型溃疡性结肠炎随机分为口服溃结2号方治疗组,口服美沙拉嗪肠溶片对照组,两组均治疗4个疗程。结果:两组治愈率及总有效率无统计学差异(P>0.05);在治疗及改善中医主要症状方面,两组组内治疗前后主要临床症状均较治疗前好转。组间比较,治疗组优于对照组(P<0.05);但对于食少症状改善两者无明显区别(P>0.05);在治疗及改善水肿、糜烂、溃疡等体征方面,治疗组对结肠镜下的改善结果明显高于对照组(P<0.05)。结论:溃结2号方与美沙拉嗪治疗总有效率无明显差别,但溃结2号方更能改善患者的腹泻、腹痛、脓血便、神疲懒言、腹胀、肢体倦怠的临床症状及充血水肿、糜烂、溃疡的体征。但两者对于患者食少的改善无明显区别。Objective:To study the clinical efficacy of Kuijie No.2 recipe in the treatment of spleen-deficiency and splenic colitis.Methods:72 cases of spleen-deficiency and spleen-type ulcerative colitis were randomly divided into oral Kuijie No.2 recipe treatment groups and oral mesalazine enteric-coated tablets.The two groups were treated for 4 courses.Results:There was no significant difference in the cure rate and total effective rate between the two groups(P>0.05).In the treatment and improvement of the main symptoms of TCM,the main clinical symptoms before and after treatment were better than before treatment.Compared with the control group,the treatment group was superior to the control group(P<0.05).However,there was no significant difference between the two groups(P>0.05).In the treatment and improvement of signs such as edema,erosion,ulcer,etc.,the treatment group was on the colon.The improvement of mirror images were significantly higher than those in the control group(P<0.05).Conclusion:There is no significant difference in the total effective rate of Kuijie No.2 recipe and Mesalazine.However,Kuijie No.2 recipe can improve patient’s diarrhea,abdominal pain,and bloody stools,dizziness,bloating,and limb burnout.Clinical symptoms and signs of congestion,edema,erosion,and ulcers.However,there is no significant difference between the two in improving the patient's food intake.

关 键 词：溃疡性结肠炎 溃结2号方 脾虚湿盛证 中医症状 结肠镜 临床观察 

分 类 号：R516.1[医药卫生—内科学]