片仔癀对糖尿病并脓毒症肝损伤的治疗作用  

Therapeutic Effect of Pien Tze Huang on Liver Damage Caused by Diabetes and Sepsis

作　　者：杨钊斌[1] 陈惠萍 赖嘉伟 邱陆阵[1] YANG Zhao-bin;CHEN Hui-ping;LAI Jia-wei;QIU Lu-zhen(Department of Internal Medicine,Zhangzhou Hospital,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建省漳州市医院内科重症监护室

出　　处：《糖尿病新世界》2019年第19期18-20,共3页Diabetes New World Magazine

基　　金：2018年漳州市科技计划项目（ZZ2018J08）

摘　　要：目的探讨片仔癀治疗糖尿病并脓毒症肝损伤的临床疗效及对炎症指标、肝功能的影响。方法选取2015年3月—2017年3月入住该院内科ICU并确诊的糖尿病并脓毒症肝损伤患者46例,按随机数字表法分为对照组和观察组,每组23例,对照组给予降糖、抗炎、抗感染、吸氧、维持水电解质及酸碱平衡等常规对症支持治疗,观察组在对照组用药基础上联合片仔癀治疗,连续治疗10 d后,比较两组临床疗效,观察两组治疗前后空腹血糖(FPG)、餐后2 h血糖量(2 hPG)、糖化血红蛋白(HbAlc)水平,同时观察两组肝功能指标变化,包括谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)。结果观察组治疗后FPG、2 hPG、HbAlc水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后血清ALT、AST、ALP水平低于对照组,差异有统计学意义(P<0.05);观察组有效缓解率高于对照组,组间比较差异有统计学意义(P<0.05)。结论片仔癀具有保肝功作用,能降低糖尿病并脓毒症肝损伤患者炎症反应,改善患者肝功能。Objective To investigate the clinical efficacy of Pien Tze Huang in the treatment of diabetic and sepsis liver injury and its influence on inflammation index and liver function.Methods From March 2015 to March 2017,46 patients with diabetes mellitus and sepsis with liver injury were enrolled in the ICU of our hospital.The patients were divided into the control group and the observation group according to the random number table.Each group had 23 cases.The control group was given conventional symptomatic supportive treatment such as hypoglycemic,anti-inflammatory,anti-infective,oxygen-absorbing,water-electrolyte and acid-base balance.The observation group was treated with Pien Tze Huang on the basis of the control group.After 10 d of continuous treatment,the clinical efficacy of the two groups was compared.The fasting blood glucose(FPG),postprandial 2 h blood glucose(2 hPG)and glycosylated hemoglobin(HbAlc)levels were observed before and after treatment.The changes of liver function indexes,including alanine aminotransferase(ALT)and aspartate aminotransferase(AST),Alkaline phosphatase(ALP).Results The levels of FPG,2 hPG and HbAlc in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The levels of serum ALT,AST and ALP in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The effective remission rate in the observation group was higher than that in the control group.There was a statistical difference between the groups and the groups(P<0.05).Conclusion Pien Tze Huang has a liver-protecting effect,which can reduce the inflammatory response of patients with diabetes and sepsis liver injury and improve liver function.

关 键 词：糖尿病 脓毒症 肝损伤 片仔癀 保肝 

分 类 号：R969[医药卫生—药理学]