不同剂量重组人生长激素对小于胎龄儿矮小症患儿相关指标的影响  

Effects of different doses of recombinant human growth hormone on related factors in dwarfism children who were smaller for gestational age

作　　者：朱一杰 ZHU Yijie(Department of Pediatric Health Care,Xi′an Third Hospital in Shaanxi Province,Xi′an,Shaanxi,710016)

机构地区：[1]陕西省西安市第三医院儿保科

出　　处：《实用临床医药杂志》2019年第19期100-102,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨大剂量重组人生长激素(rhGH)与小剂量rhGH对小于胎龄儿(SGA)矮小症患儿身高标准差的增长值(△HtSDS)、生长速率(HV)、血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)的影响。方法选取110例SGA矮小症患儿作为研究对象,按用药剂量的不同分为2组,各55例。小剂量组患儿每日服用0.10~0.15 IU/kg的rhGH,大剂量组患儿每日服用0.16~0.20 IU/kg的rhGH,对比2组的用药效果。结果治疗后6、12、24个月,大剂量组的△HtSDS、HV、血清IGF-1、IGFBP-3水平均显著高于小剂量组(P<0.05)。结论大剂量rhGH应用于SGA矮小症患儿的治疗中优势明显,对患儿△HtSDS、HV、血清IGF-1、IGFBP-3的正性影响更大。Objective To investigate the effects of high-dose recombinant human growth hormone(rhGH)and low-dose rhGH on growth value of standard height deviation(△HtSDS),growth velocity(HV),serum insulin-like growth factor-1(IGF-1)and insulin-like growth factor binding protein-3(IGFBP-3)of dwarfism children who were smaller for gestational age(SGA).Methods A total of 110 patients were selected as study subjects and were divided into two groups according to differed doses,with 55 cases per group.The patients in the low-dose group were given rhGH for 0.10~0.15 IU/kg daily,and those in the high-dose group were orally administrated rhGH for 0.16~0.20 IU/kg.The drug efficacy between the two groups was compared.Results At 6,12 and 24 months after treatment,the levels of△HtSDS,HV,blood IGF-1 and IGFBP-3 in the high dose group were higher than those in the low dose group(P<0.05).Conclusion High dose of rhGH has more obvious advantages in the treatment of SGA dwarfism children,and has more positive effects on HtSDS,HV,blood IGF-1 and IGFBP-3.

关 键 词：重组人生长激素 剂量 小于胎龄儿 矮小症 身高标准差的增长值 生长速率 血清胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 

分 类 号：R725.8[医药卫生—儿科]