达立通颗粒联合伊托必利治疗功能性消化不良临床观察  

Clinical Observation on Dalitong Granules Combined with Itopride in the Treatment of Functional Dyspepsia

作　　者：蔡清红 马松炎[1] CAI Qinghong;MA Songyan(Department of Digestive Internal Medicine,The Third People's Hospital of Huizhou,Huizhou,Guangdong,China 516000)

机构地区：[1]广东省惠州市第三人民医院消化内科

出　　处：《中国药业》2019年第22期58-60,共3页China Pharmaceuticals

基　　金：广东省惠州市科技计划项目[170511201740555]

摘　　要：目的探讨达立通颗粒联合伊托必利治疗功能性消化不良(FD)的临床疗效及对胃肠排空率和胃肠激素水平的影响。方法选取医院2017年10月至2018年6月收治的FD患者84例,按随机数字表法分为试验组和对照组,各42例。两组患者均接受常规FD治疗,并口服盐酸伊托必利胶囊(每次1粒,每日3次);治疗组患者加服达立通颗粒(每次1袋,每日1次)。两组均连续治疗4周。结果治疗组总有效率为90.48%,显著高于对照组的73.81%(P<0.05);与治疗前比较,两组患者治疗后的临床症状积分均显著降低,胃肠排空率及胃动素、胃泌素和P物质水平均显著升高,且试验组患者上述指标改善程度均显著优于对照组(P<0.05);对照组及试验组不良反应发生率相当(7.14%比9.52%,χ2=0.156,P=0.693>0.05)。结论达立通颗粒联合伊托必利治疗FD有一定疗效,能提高胃肠排空率,促进胃肠激素分泌。Objective To investigate the clinical efficacy of Dalitong Granules combined with itopride in the treatment of functional dyspepsia(FD)and its effect on gastrointestinal emptying rate and gastrointestinal hormone level.Methods Totally 84 patients with FD admitted to our hospital from October 2017 to June 2018 were selected and divided into the treatment group and the control group by the random number table method,42 cases in each group.The patients in the two groups were treated with routine FD treatment and Itopride Hydrochloride Capsules(1 capsule per time,3 times a day),on this basis,the patients in the treatment group were treated with Dalitong Granules(1 bag per time,once a day).Both groups were continuously treated for 4 weeks.Results The total effective rate of the treatment group was 90.48%,which was significantly higher than 73.81%of the control group(P<0.05).Compared with those before treatment,the clinical symptom score was significantly decreased,the gastrointestinal emptying rate and the levels of motilin,gastrin and substance P were significantly increased in the two groups,and the improvement of the above indexes in the treatment group was significantly better than that in the control group(P<0.05).The incidence of adverse reactions in the control group was similar to that in the treatment group(7.14%vs.9.52%,χ2=0.156,P=0.693>0.05).Conclusion Dalitong Granules combined with itopril has a certain effect in the treatment of FD,which can significantly improve the gastrointestinal emptying rate,promote the secretion of gastrointestinal hormone.

关 键 词：功能性消化不良 达立通颗粒 伊托必利 临床疗效 胃肠排空 胃肠激素 

分 类 号：R969.4[医药卫生—药理学] R2-031[医药卫生—药学]