胺碘酮和曲美他嗪治疗心力衰竭伴心律失常对抑制心室重构和恢复心率变异性的机制  

Mechanism of amiodarone and trimetazidine in the treatment of heart failure with arrhythmias to inhibit ventricular remodeling and recovery of heart rate variability

作　　者：李国彪[1] 王高明[1] 孙志刚[1] LI Guobiao;WANG Gaoming;SUN Zhigang(Department of Cardiology,the First People’s Hospital of Fuzhou,Jiangxi Fuzhou 344000,China)

机构地区：[1]抚州市第一人民医院心内科

出　　处：《上海医药》2019年第21期21-22,70,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨胺碘酮联合曲美他嗪治疗心衰(heart failure,HF)伴心律失常患者治疗中应用对抑制左室重构(left ventricular remodeling,LVR)以及心率变异性(heart rate variability,HRV)的影响。方法:选取80例HF患者随机分成对照组(n=40,胺碘酮治疗)和观察组(n=40,胺碘酮+曲美他嗪治疗),连续治疗3个月后比较其LVR和HRV指标和临床症状改善情况。结果:治疗后两组患者症状均明显改善,观察组效果显著优于对照组(P<0.05)。观察组患者左室射血分数、左室舒张末期内径和左室收缩末期内径等指标和SDANN、SDNN指标改善效果优于对照组(P<0.05)。结论:胺碘酮联合曲美他嗪治疗HF能够抑制心室重构、改善临床症状。Objective:To investigate the effects of amiodarone combined with trimetazidine on the inhibition of left ventricular remodeling(LVR)and heart rate variability(HRV)in patients with heart failure(HF)associated with arrhythmia.Methods:Eighty patients with HF were randomly divided into a control group treated with amiodarone and an observation group treated with amiodarone trimetazidine with 40 cases each.LVR and HRV indexes and clinical symptom improvement were compared after 3 months of continuous treatment.Results:After treatment,the symptoms in both groups were significantly improved,and the effect and some indexes such as the left ventricular ejection fraction,left ventricular end-diastolic diameter and left ventricular end-systolic diameter and the improvement of SDANN and SDNN indicators were much better in the observation group than the control group(P<0.05).Conclusion:Amiodarone combined with trimetazidine for the treatment of heart failure can inhibit ventricular remodeling and improve clinical symptoms.

关 键 词：心力衰竭 心律失常 胺碘酮 曲美他嗪 

分 类 号：R541.71[医药卫生—心血管疾病] R972.3[医药卫生—内科学]