使用动态血压监测评价经鼻饲/胃管内注入氨氯地平控制血压的临床研究  

Clinical Study on Using Ambulatory Blood Pressure Monitoring to Evaluate the Blood Pressure Control of Amlodipine Nasal/Intragastric Feeding

作　　者：陆瑾 展冠军[2] 薛尧[1,2] 曹露露 巫悦[1,2] LU Jin;ZHAN Guanjun;XUE Yao;CAO Lulu;WU Yue(Pharmacy Department,Nanjing Dachang Hospital,Jiangsu Nanjing 210048,China;Pharmacy Department,Zhongda Hospital,Southeast University,Jiangsu Nanjing 210009,China)

机构地区：[1]南京市大厂医院药剂科,江苏南京210048 [2]东南大学附属中大医院药剂科,江苏南京210009

出　　处：《中国医药导刊》2019年第9期551-554,共4页Chinese Journal of Medicinal Guide

基　　金：南京药学会——常州四药医院药学科研基金(项目编号:2017YX019;项目名称:动态血压监测评价氨氯地平(络活喜)鼻饲治疗高血压的临床降压疗效)

摘　　要：目的:探讨使用动态血压监测评价患者经鼻饲/胃管内注入氨氯地平控制血压的临床应用效果。方法:对24例经鼻饲/胃管内注入氨氯地平患者进行动态血压监测,按规定时间记录24 h收缩压/舒张压、白天收缩压/舒张压、夜间收缩压/舒张压及服药后2 h内收缩压/舒张压。结果:患者24 h收缩压(137.2±13.3)mmHg,舒张压(85.5±12.6)mmHg;白天收缩压(138.6±13.8)mmHg,舒张压(86.0±12.5)mmHg;夜间收缩压(133.1±13.2)mmHg,舒张压(85.2±15.0)mmHg;服药后2 h收缩压(135.9±16.2)mmHg,舒张压(87.8±16.3)mmHg。治疗总有效率为87.5%。结论:患者经鼻饲/胃管内注入氨氯地平后,未出现明显的快速降压及血压波动大的现象。氨氯地平经鼻饲/胃管内注入可以较好地控制血压。Objective:To explore the clinical application of evaluating amlodipine nasal/intragastric feeding with ambulatory blood pressure monitoring.Methods:Ambulatory blood pressure monitoring was performed on 24 patients who received amlodipine nasal/intragastric feeding.The 24 h systolic blood pressure(SBP)/diastolic blood pressure(DBP),daytime SBP/DBP,nighttime SBP/DBP,and SBP/DBP of 2 h after medication were recorded.Results:The 24 h SBP,24 h DBP,daily SBP,daily DBP,nighttime SBP,nighttime DBP,SBP of 2 h after medication and DBP of 2 h after medication of the patients were(137.2±13.3)mmHg,(85.5±12.6)mmHg,(138.6±13.8)mmHg,(86.0±12.5)mmHg,(133.1±13.2)mmHg,(85.2±15.0)mmHg,(135.9±16.2)mmHg and(87.8±16.3)mmHg,respectively.The total effective rate of treatment was 87.5%.Conclusion:There is no obvious rapid blood pressure drop or wide blood pressure fluctuations after nasal/intragastric feeding of amlodipine.Amlodipine with nasal/intragastric feeding can be used to control the blood pressure.

关 键 词：鼻饲/胃管内注入 氨氯地平 动态血压监测 临床应用 

分 类 号：R544.1[医药卫生—心血管疾病]