克罗诺杆菌主要毒力因子及致病机理研究进展  

Progress on main virulence factors and pathogenic mechanism of Cronobacter spp.

作　　者：费鹏 杨同香[1] 陈曦[1] 向进乐[1] 赵胜娟[1] 徐云凤 周莲昕 郭鸰[2] 康怀彬[1] FEI Peng;YANG Tong-xiang;CHEN Xi;XIANG Jin-le;ZHAO Sheng-juan;XU Yun-feng;ZHOU Lian-xin;GUO Ling;KANG Huai-bin(College of Food and Biological Engineering,Henan University of Science and Technology,Luoyang,Henan 471023,China;Key Laboratory of Dairy Science,Ministry of Education Food Science College,Northeast Agricultural University,Harbin,Heilongjiang 150030,China)

机构地区：[1]河南科技大学食品与生物工程学院,河南洛阳471023 [2]东北农业大学食品学院乳品科学教育部重点实验室,黑龙江哈尔滨150030

出　　处：《食品与机械》2019年第10期150-154,159,共6页Food and Machinery

基　　金：河南科技大学博士科研启动基金项目（编号：13480066）;河南省科技攻关项目（编号：172102110019）;河南省重点攻关项目（编号：161100110900）;国家自然科学基金（编号：31702218)

摘　　要：综述了克罗诺杆菌肠毒素、外膜蛋白、基因Inv、关键酶RpfF等主要的毒力因子在克罗诺杆菌致病过程中的作用,并从菌毛的黏附作用、克罗诺杆菌对铁的吸收作用、对唾液酸的利用能力、生物膜对克罗诺杆菌的保护作用和黏附能力的影响、外排系统对克罗诺杆菌在宿主胃肠道中存活能力的影响、耐干燥能力等几个方面总结了该病原菌的致病机理。In this study,the role of major virulence factors in the pathogenic process of Cronobacter,including enterotoxin,outer membrane protein,gene Inv,and key enzyme RpfF were reviewed.Furthermore,the pathogenic mechanism was summarized from the following aspects,i.e.the adhesion of bacterial hair,the absorption ability of iron by Cronobacter,the utilization of sialic acid,the effects of biofilm on the protection,and the adhesion of Cronobacter,the effect of efflux system on the viability of Cronobacter in host gastrointestinal tract and desiccation resistance.

关 键 词：克罗诺杆菌 致病机理 毒力因子 研究进展 

分 类 号：S85[农业科学—兽医学]