金纳米棒光热治疗肿瘤的生物安全性评估  

Assessment of Biosafety of Gold Nanorods in Photothermal Tumor Therapy

作　　者：王浩[1] 张世文[1] Wang Hao;Zhang Shiwen(First Department of Head and Neck Surgery,Yunnan Cancer Hospital&The Third Affiliated Hospital of Kunming Medical University&Yunnan Cancer Center,Kunming 650118,Yunnan,China)

机构地区：[1]昆明医科大学第三附属医院·云南省肿瘤医院头颈外一科

出　　处：《肿瘤预防与治疗》2019年第10期935-939,共5页Journal of Cancer Control And Treatment

基　　金：国家自然科学基金项目(编号:81560496);2016年度云南省高层次卫生计生技术人才项目(编号:D-201620);2018年云南省中青年学术和技术带头后备人才项目(编号:C20048)~~

摘　　要：金纳米棒具有高效的光热转换特性和良好的生物相容性,是当前医学应用研究的热点之一,目前已在细胞成像、药物或者基因运载以及肿瘤光热治疗等方面开展系列研究。虽然金为惰性金属材料,但金纳米微粒仍然会存在某些金属毒理特性,且金纳米棒在制备过程中常常还会用到的一些毒性化学物质,因此金纳米棒的生物安全性成为临床应用研究要解决的首要问题之一。本文拟从金纳米棒理化特性、化学修饰、生物毒性及体内代谢和安全等方面进行综述,旨为金纳米棒进行医学研究提供生物安全相关理论依据。Gold nanorods have become a hot spot in medical application due to their high efficiency in photothermal con-version and good biocompatibility.Currently,a series of studies have been carried out on cell imaging,drug or gene delivery,and photothermal tumor therapy.Although gold is an inert metal material,gold nanoparticles still have some toxicological properties of metal.Moreover,some toxic chemicals are often used in the preparation of gold nanorods.Therefore,the bio-logical safety of gold nanorods has become one of the primary problems to be solved in clinical application research.This pa-per intends to review the physical and chemical properties,chemical modification,biological toxicity,metabolism and safety of gold nanorods,and provide theoretical basis for biosafety in medical research of gold nanorods.

关 键 词：金纳米棒 光热治疗 生物安全性 评估 

分 类 号：R312[医药卫生—基础医学] R730.55