三唑啉酮磺酰胺类化合物的设计合成与生物活性  

Design, Synthesis, and Biological Activities of Novel Triazolione Containing Sulfamide

作　　者：吴峤 张静静 杨吉春 WU Qiao;ZHANG Jing-jing;YANG Ji-chun(State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Research Institute,Shenyang 110021,China;Patent Examination Cooperation Jiangsu Center of the Patent Office,CNIPA,Suzhou 215010,Jiangsu,China)

机构地区：[1]沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室 [2]国家知识产权局专利局专利审查协作江苏中心

出　　处：《农药》2019年第10期708-710,共3页Agrochemicals

摘　　要：[目的]为了发现具有更好生物活性的新结构化合物。[方法]利用中间体衍生化方法合成三唑啉酮磺酰胺类化合物。[结果]合成了11个结构新颖的三唑啉酮磺酰胺类化合物,结构经过1H NMR等分析确证,并进行了生物活性测试。[结论]生物活性表明此类化合物对小麦白粉病和水稻稻瘟病具有一定的防效。[Aims] This study aims to discover novel compounds with high activity. [Me thods] Four of triazolione containing sulfamide compounds were designed and synthesized by means of "Intermediate Derivatization Method".[Res ults] The structures of these four synthesized compounds were confirmed by ~1H NMR and biological activities of synthesized triazolione compounds were tested. [Conclusions] Biological activity indicated that these compounds had certain control effects against wheat powdery mildew and rice blast.

关 键 词：三唑啉酮磺酰胺 合成 生物活性 杀菌剂 

分 类 号：TQ460.3[化学工程—制药化工]