同胞间致敏过敏原的分布与相似度分析  

Distribution and similarity of allergens in children in the same family

作　　者：陈晓倩[1] 叶慧清 陈壮桂[2] 钟韩荣[1] 罗昌寿[1] 何丽仪[1] 刘明伟[1] Chen Xiaoqian;Ye Huiqing;Chen Zhuanggui;Zhong Hanrong;Luo Changshou;He Liyi;Liu Mingwei(Department of Pediatrics,First People′s Hospital of Foshan City,Foshan 528000,China;Department of Pediatrics,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]广东省佛山市第一人民医院儿科,528000 [2]中山大学附属第三医院儿科,广州510630

出　　处：《中国综合临床》2019年第6期527-531,共5页Clinical Medicine of China

基　　金：佛山市卫生和计划生育局医学科研课题(20180004)。

摘　　要：目的调查并分析同一遗传背景和环境因素下,具有易感性的同胞儿童过敏原的相似度。方法收集2013年1月至2017年12月在佛山市第一人民医院、中山大学附属第三医院儿科及耳鼻喉科门诊就诊或住院治疗的0~15岁过敏性疾病的患儿及其同胞兄弟姐妹共142对,284例,以兄或姐为年长组(142例),以弟或妹为年少组(142例)。分别做问卷调查及通过Allergy Screen过敏原检测系统(由德国MEDIWISS公司研发)测定血清过敏原sIgE,并分析其过敏原的相似度。结果共纳入同胞兄弟姐妹142对(284例),均有不同程度过敏性疾病系统性症状,包括呼吸道症状[咳嗽(年长组47例,年少组32例),χ^2=3.946,P=0.047]、鼻塞(年长组41例、年少组19例,χ^2=10.227,P=0.001)、流涕(年长组46例,年少组26例,χ^2=7.442,P=0.006]、消化道症状[腹痛(年长组11例,年少组7例,χ^2=4.63,P=0.031)]、皮肤症状[荨麻疹(年长组18例、年少组8例,χ^2=4.234,P=0.037)]等,差异有统计学意义。部分患儿同时有多器官系统症状。年长组及年少组在早期使用抗生素、生产方式、6月龄内的喂养方式差异均无统计学意义(P均>0.05)。两组间的屋尘螨与蟑螂(r=0.831,P<0.05),狗毛与屋尘(r=0.717,P<0.05),柏、榆、柳、桦、栎、枫、胡桃、梧桐、杨与点青、分枝、烟曲、黑曲(r=0.683,P<0.05)有关。结论同一遗传背景及环境因素下,同胞间的过敏原具有相似度。Objective To investigate and analyze the similarities of allergens in children of the same family with susceptibility to the same genetic background and environmental factors.Methods From January 2013 to December 2017,a total of 142 pairs of children with allergic diseases aged 0-15 years and their siblings(284 cases)were collected from the outpatient or hospitalized treatment of Pediatrics and otolaryngology department of the First People′s Hospital of Foshan City,the Third Affiliated Hospital of Sun Yat-sen University.The elder group was brother or sister(142 cases),and the younger group was brother or sister(142 cases).The serum allergen sIgE was tested by Allergy Screen allergen detection system(developed by Germany MEDIWISS Company)and the similarity of allergens was analyzed.Results A total of 142 siblings(284 cases)had systemic symptoms of allergic diseases in varying degrees,including respiratory symptoms(cough(47 cases in the old group,32 cases in the young group),χ^2=3.946,P=0.047),nasal obstruction(41 cases in the old group,19 cases in the young group,χ^2=10.227,P=0.001),runny nose(46 cases in the old group,26 cases in the young group,χ^2=7.442,P=0.006),gastrointestinal symptoms(abdominal pain(11cases in the old group,7 cases in the young group,χ^2=4.63,P=0.031),skin symptoms(urticaria(18 cases in the old group,8 cases in the young group,χ^2=4.234,P=0.037))and so on,the difference was statistically significant.Some children have multiple organ system symptoms at the same time.There was no significant difference between the old group and the young group in the early use of antibiotics,mode of production and feeding mode within 6 months(all P>0.05).Among the two groups,house dust mite and cockroach(r=0.831,P<0.05),dog hair and house dust(r=0.717,P<0.05),cypress,elm,willow,birch,oak,maple,walnut,sycamore,poplar and Dianqing,branching,yanqu,and heiqu(r=0.683,P<0.05).Conclusion With the same genetic background and the same environmental factors,the allergens in siblings are similar.

关 键 词：同胞 致敏过敏原 相似度 

分 类 号：R72[医药卫生—儿科]