聚乙烯胺及其衍生物在生物医学工程中的应用进展  

Progress on Applications of Poly (Vinyl Amine) and its Derivatives in Biomedical Engineering

作　　者：朱文仙 袁明 唐华东[1] Zhu Wenxian;Yuan Ming;Tang Huadong(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310000,China)

机构地区：[1]浙江工业大学化学工程学院

出　　处：《中国生物医学工程学报》2019年第4期490-497,共8页Chinese Journal of Biomedical Engineering

基　　金：浙江省自然科学基金杰出青年基金(LR12B04002)

摘　　要：聚乙烯胺(PVAm)是氨基聚合物中一级胺含量最高的水溶性大分子,具有聚阳离子特性、pH刺激响应性、高反应活性等特征,近10年来已在生物医学、石油化工、造纸印染、污水处理等诸多领域获得了广泛应用。系统介绍聚乙烯胺及其衍生物在生物医学领域的研究进展,主要从基因转染、药物治疗、组织工程等3个方面,详细总结近10年来的研究成果,分析对比了聚乙烯胺及其衍生物在这些领域应用的优势与缺点,指出其在这些技术领域的发展趋势,对聚乙烯胺衍生物的设计、合成及其在生物医学领域的应用开发具有指导意义。Poly(vinyl amine)(PVAm)is a water soluble macromolecule containing the highest primary amine groups among all amino polymers.PVAm is featured by its polycation property,pH-responsive behaviour and high reactive activity,and has various applications in biomedical science,petrochemical engineering,paper manufacturing,textile printing,and wastewater treatment.In this work,the research progress on the applications of PVAm and its derivatives in biomedical engineering was reviewed and the research results produced in recent ten years in the fields of gene transfection,drug therapy and tissue engineering were summarized.The advantages and disadvantages of PVAm and its derivatives in these fields were comparatively analyzed and the development tendency in these technology areas was presented,which could provide forward guidance for the design and synthesis of PVAm derivatives and the exploration of their applications in biomedical engineering.

关 键 词：聚乙烯胺 基因转染 药物治疗 组织工程 

分 类 号：R318[医药卫生—生物医学工程]