磷酸钙支架材料促血管生成影响的研究  

The Effect of Calcium Phosphate Scaffold on Angiogenesis

作　　者：谭艳林 罗春媛 陈凯瑞 张强[1] 熊博凯 刘秀飘 杨佩佩 杨羽晨 Tan Yanlin;Luo Chunyuan;Chen Kairui;Zhang Qiang;Xiong Bokai;Liu Xiupiao;Yang Peipei;Yang Yuchen(Department of Oral&Maxillofacial Surgery,First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Laboratory of Oral Science,Stomatological Hospital of Guangzhou Medical University,Guangzhou 510140,China;Department of Oral&Maxillofacial Surgery,Guangzhou Women and Children Center,Guangzhou 510140,China)

机构地区：[1]南昌大学第一附属医院口腔颌面外科,南昌330006 [2]广州医科大学附属口腔医院牙周科口腔医学重点实验室,广州510140 [3]广州市妇女儿童医疗中心口腔颌面外科,广州510140

出　　处：《中国生物医学工程学报》2019年第4期498-502,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(81560189,81260169);广州医科大学教育规划基金(2016A30)

摘　　要：支架材料对血管生成的诱导作用可以提高成骨的容积以及骨组织移植的成功率,所以血管生成是骨组织形成的先决条件之一。如何在支架材料中构建血管网络或在材料诱导成骨中促进血管的生成,已经在世界范围内广泛开展。研究表明,磷酸钙作为骨组织工程研究中最常用的支架材料,可以通过结构优化赋予其良好的骨传导性和骨诱导性,但磷酸钙支架的应用研究还没有充分认识到其在血管生成方面的影响和所起的关键作用。综述磷酸钙支架材料对血管生成的影响,并强调其在骨组织工程中促血管生成的重要性。Angiogenesis in scaffold materials can increase the volume of osteogenesis and the success rate of bone product transplantation,therefore is one crucial condition for bone tissue formation.Researches of vascular networks in scaffold materials or induce angiogenesis in osteogenesis by scaffold materials have been intensively conducted woldwide.Calcium phosphate is the most commonly used scaffold material in bone tissue engineering research.Studies have demonstrated that it can be given good bone conduction and osteoinductivity through structural optimization,but the application research of calcium phosphate scaffold has not fully realized its angiogenesis meaning.This article reviewed the effects of calcium phosphate scaffolds on angiogenesis and addressed the importance of angiogenesis in bone tissue engineering.

关 键 词：磷酸钙 支架 血管生成 

分 类 号：R318[医药卫生—生物医学工程]