神经酰胺在冠心病临床诊断和风险预测中的价值  

Value of ceramide in the diagnosis and risk prediction of coronary artery disease

作　　者：屠琛琛[1] 万宝艳[1] 赵昔良 李彩霞 武红梅 张丽丽 栗琳 曾勇 Tu Chenchen;Wan Baoyan;Zhao Xiliang;Li Caixia;Wu Hongmei;Zhang Lili;Li Lin;Zeng Yong(Beijing AnzhenHospital,Capital Medical University,Beijing 100029,China;Beijing Health Biotech Co.Ltd.,Beijing 102206,China)

机构地区：[1]首都医科大学附属北京安贞医院心内科,北京100029 [2]北京豪思生物科技有限公司,北京102206

出　　处：《中华医学杂志》2019年第39期3089-3092,共4页National Medical Journal of China

摘　　要：目的研究神经酰胺在冠状动脉狭窄程度、临床诊断及风险预测方面的临床价值。方法研究人群为2018年3—8月北京安贞医院心内科1B病房拟诊冠心病入院的890例患者,检测血浆中4种(Cer1、Cer2、Cer3、Cer4)神经酰胺的水平,比较冠脉不同狭窄程度与神经酰胺指标的相关性,分析神经酰胺对急性心肌梗死的辅助诊断价值,并随访患者出院后一年主要心脑血管不良事件发生情况,评估神经酰胺对冠心病和脑卒中风险的预测价值。结果研究显示神经酰胺指标在不同冠脉狭窄程度组别间的差异没有统计学意义(P>0.05),用ROC曲线分析神经酰胺对急性心肌梗死的诊断价值,结果显示曲线下面积为0.725。结论神经酰胺对于急性心肌梗死具有一定的辅助诊断价值,对于MACCE预测也有一定意义。神经酰胺与冠脉病变程度及冠心病预后的关系有待进一步研究。Objective To evaluate the clinical values of 4 types of ceramides(Cer1,Cer2,Cer3,Cer4)in the coronary artery stenosis,clinical diagnosis and risk prediction.Methods A total of 890 patients with coronary heart disease(CHD)in Beijing Anzhen Hospital between March 2018 and August 2018 were enrolled.The relationships between different degrees of coronary artery stenosis and ceramide levels was investigated.Diagnostic value of ceramides on acute myocardial infarction was analyzed.Meanwhile,Major adverse cardiac and cerebrovascular events(MACCE)in 1 year after discharging were collected to evaluate the predictive value of ceramides on risk of CHD and stroke.Results This study showed that there were no significant differences of ceramide levels in CHD patients with different degrees of coronary artery stenosis(P>0.05),and the area under receiver operating characteristic(ROC)curve in the diagnosis of acute myocardial infarction patients was 0.725.Conclusions Ceramide is proved to be helpful in the diagnosis of acute myocardial infarction and MACCE prediction.The relationships between ceramide and degrees of coronary artery stenosis as well as the prognosis of CHD need further elucidation.

关 键 词：神经酰胺 冠心病 主要心脑血管不良事件 心肌梗死 

分 类 号：R54[医药卫生—心血管疾病]