复方氨基酸胶囊在经皮附睾穿刺取精-卵细胞质内单精子注射治疗梗阻性无精子症中的应用  

Medication of Compound Amino Acid Capsules for obstructive azoospermia patients undergoing percutaneous epididymal sperm aspiration and intracytoplasmic sperm injection

作　　者：谷龙杰 靳镭 杨柳[2] 杨娟[2] 王成[2] 殷莉 GU Long-jie;JIN Lei;YANG Liu;YANG Juan;WANG Cheng;YIN Li(Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;Center of Reproductive Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院生殖医学中心,湖北武汉430030

出　　处：《中华男科学杂志》2019年第10期905-908,共4页National Journal of Andrology

基　　金：国家自然科学基金(81701520)~~

摘　　要：目的:探讨复方氨基酸胶囊在采用经皮附睾穿刺取精(PESA)-ICSI治疗梗阻性无精子症中的应用价值。方法:回顾性分析了134例梗阻性无精子症患者的PESA-ICSI周期数据,根据用药情况,把患者分为两组:治疗组64例,年龄(32.1±5.7)岁,PESA-ICSI术前连续服用复方氨基酸胶囊3个月;对照组70例,年龄(32.3±4.5)岁,术前没有服用任何药物。将治疗组与对照组的受精率、卵裂率、优质胚胎率及囊胚形成率进行对比。结果:两组患者在配偶年龄、获卵数、受精率、卵裂率中均未见显著差异,治疗组和对照组的优质胚胎率分别为(74.3±12.6)%和(67.4±13.8)%,差异具有显著性(P<0.05)。治疗组和对照组的囊胚形成率分别为(66.8±14.6)%和(60.3±14.2)%,差异具有显著性(P<0.05)。结论:复方氨基酸胶囊可提高梗阻性无精子症PESA-ICSI治疗的优质胚胎率及囊胚形成率。Objective: To investigate the effects of Compound Amino Acid Capsules(CAAC) for obstructive azoospermia(OA) patients undergoing percutaneous epididymal sperm aspiration(PESA) and ICSI. Methods: We retrospectively studied 134 cycles of PESA-ICSI in OA males, who were divided into a CAAC group(n = 64) and a control group(n = 70), the former, aged(32.1 ± 5.7) years, treated with CAAC for 3 months before PESA-ICSI while the latter, aged(32.3 ± 4.5) years, left untreated. We compared the rates fertilization, cleavage, high-quality embryos and blastocyst formation between the two groups of patients.Results: Compared with the control, the CAAC group achieved significantly higher rates of high-quality embryos([67.4 ± 13.8]% vs [74.3 ± 12.6]%, P < 0.05) and blastocyst formation([60.3±14.2]% vs [66.8±14.6]%, P < 0.05), but no statistically significant differences were observed between the two groups in the ages of the males and females, number of oocytes retrieved, or the rates of fertilization and cleavage. Conclusion: Medication of Compound Amino Acid Capsules can effectively improve the rates of high-quality embryos and blastocyst formation in obstructive azoospermia patients undergoing PESA-ICSI.

关 键 词：复方氨基酸 梗阻性无精子症 卵细胞质内单精子注射 优质胚胎率 囊胚 

分 类 号：R698[医药卫生—泌尿科学]