胺碘酮和索他洛尔治疗儿童室性心律失常的疗效及其对血清脑型利钠肽、超敏C反应蛋白水平的影响  

Amiodarone and Sotalol in the Treatment of Ventricular Arrhythmia in Children and Its Effects on Levels of Serum Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein

作　　者：杨慧敏[1] 王芳洁 孙琪青[1] Yang Huimin;Wang Fangjie;Sun Qiqing(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Henan Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院河南省儿童医院郑州儿童医院

出　　处：《儿科药学杂志》2019年第11期17-20,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨胺碘酮和索他洛尔对室性心律失常患儿血清脑型利钠肽(BNP)、超敏C反应蛋白(hs-CRP)水平的影响。方法:选取2016年4月至2018年3月我院收治的90例室性心律失常患儿按随机数字表法分为胺碘酮组和索他洛尔组各45例,两组患儿分别给予胺碘酮和索他洛尔治疗,比较两组患儿室性心律失常治疗效果,治疗前后血清BNP和hs-CRP水平,心电图PR间期和QT间期,复律时间及不良反应发生情况。结果:胺碘酮组治疗总有效率为88.89%,与索他洛尔组的84.44%比较差异无统计学意义(P>0.05)。治疗后,胺碘酮组血清BNP、hs-CRP水平低于索他洛尔组(P<0.05),心电图PR间期、QT间期与索他洛尔组比较差异无统计学意义(P>0.05),复律时间短于索他洛尔组(P<0.05)。胺碘酮组总不良反应发生率与索他洛尔组比较差异无统计学意义(P>0.05)。结论:胺碘酮和索他洛尔对室性心律失常患儿均有一定治疗效果,其中胺碘酮更能有效改善患儿血清BNP和hs-CRP水平,促进心律恢复。Objective:To investigate the effects of amiodarone and sotalol on the levels of serum brain natriuretic peptide( BNP) and high-sensitivity C-reactive protein( hs-CRP) in children with ventricular arrhythmia. Methods:Totally 90 children with ventricular arrhythmia admitted into in our hospital from Apr. 2016 to Mar. 2018 were extracted to be divided into the amiodarone group and the sotalol group via the random number table,with 45 cases in each group. Two groups were respectively given amiodarone and sotalol. The therapeutic effects of ventricular arrhythmia,serum BNP and hs-CRP levels( P < 0. 05), ECG PR interval and QT interval,cardiopulmonary resuscitation time before and after treatment and adverse drug reactions in two group were compared. Results:The effective rate of amiodarone group was 88. 89%,with no statistically significant difference compared with 84. 44% in sotalol group( P>0. 05). After treatment,the serum BNP and hs-CRP levels in the amiodarone group were lower than those in the sotalol group( P <0. 05),there was no statistically significant difference in the ECG PR interval and QT interval between two groups( P>0. 05),and the cardiopulmonary resuscitation time in the amiodarone group was shorter than that in the sotalol group( P<0. 05). There was no significant difference in the incidence of total adverse drug reactions between the amiodarone group and the sotalol group( P>0. 05). Conclusion:Amiodarone and sotalol have certain therapeutic effects on children with ventricular arrhythmia. And amiodarone can effectively improve serum BNP and hs-CRP levels in children and promote the recovery of heart rhythm.

关 键 词：胺碘酮 索他洛尔 室性心律失常 脑型利钠肽 超敏C反应蛋白 

分 类 号：R725.4[医药卫生—儿科]