黄体类固醇激素受体的结构功能及其生理调节  

The Structure, Functions and Physiological Regulation of Steroid Hormone Receptors in the Corpus Luteum

作　　者：张经伟 张正红[1] 王正朝[1] Zhang Jingwei;Zhang Zhenghong;Wang Zhengchao(Provincial Key Laboratory for Developmental Biology and Neurosciences,College of Life Sciences,Fujian Normal University,Fuzhou 350007,China)

机构地区：[1]福建师范大学生命科学学院福建省发育与神经生物学重点实验室

出　　处：《中国细胞生物学学报》2019年第8期1628-1632,共5页Chinese Journal of Cell Biology

基　　金：福建省自然科学基金(批准号:2016J01145、2017J01626);国家级大学生创新创新训练计划项目(批准号:201910394023);福建省教育厅科技项目(批准号:JAT160118、JZ160426);福建师范大学教改项目(批准号:Y201809、P201801016);大学生创新创新训练计划项目(批准号:CXXL2019268、CXXL2019274)资助的课题~~

摘　　要：在哺乳动物中,黄体的主要功能是合成并分泌孕酮,同时还合成适量的雌二醇。孕酮不但是发情周期长短的主要调节因子,而且也为胚胎植入与发育创造合适条件。这些类固醇激素通过特异性核受体对其靶细胞发挥作用,这些受体又属于受体依赖性转录因子家族。其中,孕酮是通过其核受体亚型A或B对靶细胞发挥生理功能,而雌二醇是通过其α或β受体对靶细胞发挥生理功能。另外,这些类固醇激素还可以通过细胞膜上类固醇激素结合蛋白,迅速激活胞内信号通路发挥功能,包括孕酮膜受体组分1和2、孕酮膜受体α、β和γ,以及G蛋白偶联的雌二醇受体。该文通过阐述黄体类固醇激素受体的分子结构、生理功能及其调节机制,旨在进一步理解类固醇激素受体在黄体生理功能调节中的重要作用。In mammals, the main founctions of corpus lutea is to synthesize and secrete progesterone, besides the moderate amounts estradiol synthesis. Progesterone is not only the main regulator of estrous cycle duration, but also creates a suitable condition for embryo implantation and development. These steroid hormones act on the target cells through the specific nuclear receptors, which also belong to the family of receptor-dependent transcription factors. For example, progesterone plays a physiological role in the target cells through nuclear progesterone receptor isoforms A and B, while estradiol through α and β receptors. In addition, these steroid hormones may rapidly activate the appropriate intracellular signaling pathways for their physiological functions through the membrane steroid-binding proteins, like the progesterone receptor membrane component 1 and 2, the membrane progestin receptors alpha, beta and gamma, and the G protein-coupled estrogen receptor. The article reviewed the molecular structure, physiological functions and its regulatory mechanism of luteal steroid hormone receptors, in order to further understand the important role of steroid hormone receptors in the regulation of physiological functions in the corpus luteum.

关 键 词：孕酮受体 雌二醇受体 孕酮 黄体 

分 类 号：R71[医药卫生—妇产科学]