腰交感神经节脉冲射频术对糖尿病神经痛的疗效  

Efficacy of lumbar sympathetic ganglion pulsed radiofrequency in treatment of diabetic neuropathic pain

作　　者：黄翔[1] 王汉兵[1] 李晓宏[1] 汤达承 陈盼 Huang Xiang;Wang Hanbing;Li Xiaohong;Tang Dacheng;Chen Pan(Department of Anesthesiology,First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]佛山市第一人民医院麻醉科,528000

出　　处：《中华麻醉学杂志》2019年第7期844-847,共4页Chinese Journal of Anesthesiology

摘　　要：目的评价腰交感神经节脉冲射频术对糖尿病神经痛的疗效.方法选取糖尿病神经痛患者48例,年龄45~75岁,病程4~7年,性别不限,采用随机数字表法分为2组(n=24):对照组(C组)和脉冲射频组(P组).C组常规药物治疗,P组在常规药物治疗的基础上行双侧腰交感神经节脉冲射频术.于治疗前和治疗4周时采用ELISA法测定血清TNF-α、IL-6水平.于治疗前、治疗1、2和4周时行VAS评分.于治疗4周时记录疗效程度,计算总有效率.记录脉冲射频术相关并发症和药物相关不良反应的发生情况.结果与C组比较,P组治疗后VAS评分、血清TNF-α、IL-6浓度降低,总有效率和疗效程度升高(P<0.05).患者均未见脉冲射频术相关并发症和药物相关不良反应发生.结论腰交感神经节脉冲射频术可缓解患者糖尿病神经痛.Objective To evaluate the efficacy of lumbar sympathetic ganglion pulsed radiofrequency(PRF)in treatment of diabetic neuropathic pain.Methods Forty-eight patients of both sexes with diabetic neuropathic pain,aged 45-75 yr,with the course of disease 4-7 yr,were divided into 2 groups(n=24 each)using a random number table method:control group(C group)and PRF group(P group).Group C was treated with conventional drugs.Bilateral lumbar sympathetic ganglion PRF was performed on the basis of conventional drug therapy in group P.The serum concentrations of tumor necrosis factor-alpha and interleukin-6 were measured by enzyme-linked immunosorbent assay.The visual analogue scale score was recorded before treatment and at 1,2 and 4 weeks of treatment.The degree of efficacy was recorded at 4 weeks of treatment,and the total effective rate was calculated.Results Compared with group C,the visual analogue scale score and serum concentrations of tumor necrosis factor-alpha and interleukin-6 were significantly decreased,and the total effective rate and degree of curative efficacy were increased in group P(P<0.05).No pulsed radiofrequency-related complications or drugs-related adverse reactions were found in two groups.Conclusion Lumbar sympathetic ganglion PRF can effectively relieve diabetic neuropathic pain in the patients.

关 键 词：神经节 交感 脉冲射频术 糖尿病神经病变 

分 类 号：R47[医药卫生—护理学]