TNFRSF11A和TNFRSF11B基因多态性与HCV感染转归的关系  

Association between TNFRSF11A and TNFRSF11B gene polymorphisms and the outcome of hepatitis C virus infection

作　　者：巫晶晶 黄鹏[1] 岳明[2] 汪春晖 吴超[4] 邵建国[5] 薛红 符祖强 卓凌云 喻荣彬[1] 张云[1,3] Wu Jingjing;Huang Peng;Yue Ming;Wang Chunhui;Wu Chao;Shao Jianguo;Xue Hong;Fu Zuqiang;Zhuo Lingyun;Yu Rongbin;Zhang Yun(Key Laboratory of Infectious Diseases,Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing 211166,China;Department of Infectious Diseases,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Eastern Theater Command Center for Disease Prevention and Control,Nanjing 210002,China;Department of Infectious Diseases,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Gastroenterology,The Third People's Hospital of Nantong Affiliated to Nantong University,Nantong 226001,China;Fourth Ward,The Third People's Hospital of Nantong Affiliated to Nantong University,Nantong 226001,China)

机构地区：[1]南京医科大学公共卫生学院流行病与卫生统计学系传染病重点实验室,211166 [2]南京医科大学第一附属医院感染科,210029 [3]东部战区疾病预防控制中心,南京210002 [4]南京大学医学院附属鼓楼医院感染科,210008 [5]南通大学附属南通市第三人民医院消化科,226001 [6]南通大学附属南通市第三人民医院四病区,226001

出　　处：《中华流行病学杂志》2019年第10期1291-1295,共5页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81773499,81703273,81502853);江苏省自然科学基金(BK20171054,BK20151026)。

摘　　要：目的探索肿瘤坏死因子受体超家族成员11A(TNFRSF11A)和11B(TNFRSF11B)基因多态性与丙型肝炎病毒(HCV)感染转归的关系.方法以2008-2016年纳入的749例持续感染者、494例自限清除者和1486例对照者作为研究对象开展病例对照研究,利用TaqMan-MGB探针法检测TNFRSF11A rs1805034和TNFRSF 11B rs2073617两个位点的基因型,分析它们在不同人群中的分布情况.结果共显性模型结果显示,与携带TNFRSF11B rs2073617 TT基因型的个体相比,携带CC基因的个体易发生HCV感染慢性化(OR=1.517,95%CI:1.055~2.181,P=0.024).隐性模型结果显示,与携带rs2073617 TT或TC基因型的个体相比,携带CC基因的个体易发生HCV感染慢性化(OR=1.435,95%CI:1.033~1.996,P=0.032);相加模型显示,随着携带C等位基因个数的增加,个体发生HCV感染慢性化的风险亦可增加(OR=1.204,95%CI:1.013~1.431,P=0.035).结论TNFRSF 11B rs2073617的基因多态性与HCV感染慢性化可能存在关联.Objective To explore the relationship between the tumor necrosis factor receptor superfamily members 11A(TNFRSF11A)and 11B(TNFRSF11B)gene polymorphisms and the outcome of hepatitis C virus(HCV)infection.Methods In this case-control study,749 cases of persistent HCV infection,494 cases of spontaneous clearance and 1486 control subjects were included from 2008 to 2016.TaqMan-MGB probe method was used to detect the genotype of TNFRSF11A rs1805034 and TNFRSF11B rs2073617.The genotypes distribution of the two single nucleotide polymorphisms(SNP)were analyzed in different populations.Results Co-dominant model showed that individuals carrying the rs2073617 CC genotype were prone to have chronic HCV infection,compared with individuals carrying the rs2073617 TT genotype(OR=1.517,95%CI:1.055-2.181,P=0.024).Recessive model results showed that individuals carrying rs2073617 CC genotype were more likely to develop chronic HCV infection compared with individuals carrying rs2073617 TT or TC genotype(OR=1.435,95%CI:1.033-1.996,P=0.032).Additive model showed that the risk for chronic HCV infection increased with the increase of the number of rs2073617 C alleles(OR=1.204,95%CI:1.013-1.431,P=0.035).Conclusion The genetic polymorphism of TNFRSF11B rs2073617 might be related with the chronicity of HCV infection.

关 键 词：丙型肝炎病毒 基因多态性 肿瘤坏死因子受体超家族成员11A 肿瘤坏死因子受体超家族成员11B 

分 类 号：R51[医药卫生—内科学]