脑积水发病机制的研究进展  

Advances in research on the pathogenesis of hydrocephalus

作　　者：詹潮鸿 张向阳[1] 肖格磊[1] ZHAN Chaohong;ZHANG Xiangyang;XIAO Gelei(Department of Neurosurgery,Diagnosis and Treatment Center for Hydrocephalus,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院神经外科脑积水诊疗中心

出　　处：《中南大学学报（医学版）》2019年第10期1188-1195,共8页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(2019JJ50949);湖南省卫生健康委员会科研项目(B2019187)~~

摘　　要：脑积水是一种常见但病因复杂的神经系统疾病,以脑脊液在脑室系统及蛛网膜下腔内聚积并不断增长为特征,既可由先天性遗传因素导致,也可由后天脑外伤、脑出血等疾病诱发。脑脊液的产生与被吸收进入静脉窦的不平衡、脑脊液循环通路受阻或者脑室内渗透压维持功能紊乱均能导致脑脊液增多、脑室扩张。Hydrocephalus is a common neurological disease with complex etiology.It is characterized by the accumulation and continuous growth of cerebrospinal fluid in the ventricular system and subarachnoid space.Hydrocephalus can be caused by congenital genetic factors,brain trauma and cerebral hemorrhage.Th rough the eff orts of many researchers,the pathogenesis of hydrocephalus is being completed,but it has not been fully explained.The imbalance of cerebrospinal fluid production and absorption into the sinus,and disorder of the cerebrospinal fluid circulation pathway or the osmotic pressure maintenance in the ventricle can lead to increased cerebrospinal fl uid and ventricular dilatation.

关 键 词：脑积水 发病机制 循环理论 渗透理论 

分 类 号：R65[医药卫生—外科学]