Nanocrystals for large Stokes shift-based optosensing  

作　　者：Ronghui Zhou Xiaomei Lu Qin Yang Peng Wu 

机构地区：[1]State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China [2]Analytical&Testing Center,Sichuan University,Chengdu 610064,China [3]College of Light Industry and Textile and Food Engineering,Sichuan University,Chengdu 610065,China

出　　处：《Chinese Chemical Letters》2019年第10期1843-1848,共6页中国化学快报（英文版）

基　　金：financial support from the Youth Science Foundation of Sichuan Province (No. 2016JQ0019);the Postdoctoral Science Foundation of China (No. 52018M633359)

摘　　要：Stokes shift is an important feature of fluorescence, which reveals the energy loss between the excitation and the emission. For most fluorescent materials(e.g., organic dyes and proteins), the large overlap between the absorption and emission spectra endow them a small Stokes shift that induced reabsorption by fluorophore itself. Although the self-absorption can be effectively reduced due to the emergence of fluorescent nanomaterials, fluorescence attenuation is still observed in aggregated or concentrated nanocrystals, causing reduced sensitivity of biosensors. Therefore, increasing the Stokes shift can effectively improve the performance of nano-agents based biosensing. In this critical review, through understanding the Stokes shift from the viewpoint of self-absorption, the influence of Stokes shift on fluorescence properties are discussed. Based on the principle of changing the Stokes shift of fluorescent nanomaterials, we described the methods for constructing various optically large Stokes shift-based nanomaterials, and the application of these nanocrystals in biosensing is especially concerned in this review.Stokes shift is an important feature of fluorescence, which reveals the energy loss between the excitation and the emission. For most fluorescent materials(e.g., organic dyes and proteins), the large overlap between the absorption and emission spectra endow them a small Stokes shift that induced reabsorption by fluorophore itself. Although the self-absorption can be effectively reduced due to the emergence of fluorescent nanomaterials, fluorescence attenuation is still observed in aggregated or concentrated nanocrystals, causing reduced sensitivity of biosensors. Therefore, increasing the Stokes shift can effectively improve the performance of nano-agents based biosensing. In this critical review, through understanding the Stokes shift from the viewpoint of self-absorption, the influence of Stokes shift on fluorescence properties are discussed. Based on the principle of changing the Stokes shift of fluorescent nanomaterials, we described the methods for constructing various optically large Stokes shift-based nanomaterials, and the application of these nanocrystals in biosensing is especially concerned in this review.

关 键 词：STOKES SHIFT SELF-ABSORPTION BAND gap Optical NANOCRYSTALS BIOSENSING 

分 类 号：TB3[一般工业技术—材料科学与工程]