10例寻常型银屑病合并大疱性类天疱疮临床分析  

Clinical analysis of 10 patients with psoriasis vulgaris complicated with bullous pemphigoid

作　　者：曹珊 王娜[2] 颜潇潇[2] 张朝霞[2] 周盛基[2] 王广进[2] 杜东红[2] 杨青[2] 于长平[2] 周桂芝[2] 杨宝琦[2] 张福仁[2] CAO Shan;WANG Na;YAN Xiaoxiao;ZHANG Zhaoxia;ZHOU Shengji;WANG Guangjin;DU Donghong;YANG Qing;YU Changping;ZHOU Guizhi;YANG Baoqi;ZHANG Furen(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250062,China;Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250062,China)

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,济南250062 [2]山东省皮肤病医院&山东省皮肤病性病防治研究所,山东第一医科大学&山东省医学科学院,济南250022

出　　处：《中国麻风皮肤病杂志》2019年第11期643-646,共4页China Journal of Leprosy and Skin Diseases

摘　　要：目的:总结寻常型银屑病合并大疱性类天疱疮患者的临床特征及治疗方法。方法:回顾性分析2016年1月至2018年12月我院住院患者中诊断为寻常型银屑病合并大疱性类天疱疮的临床资料。结果:共发现10例寻常型银屑病合并大疱性类天疱疮患者,其中男9例,女1例,平均年龄为(59.90±10.18)岁,银屑病均先于大疱性类天疱疮发病。8例患者水疱发生于银屑病斑块上,2例水疱发生于外观正常的皮肤上。9例患者采用糖皮质激素和/或免疫抑制剂治疗,1例患者应用口服四环素、烟酰胺配合光疗治疗。出院后随访150~1065天,7例患者无新发水疱,银屑病皮损病情稳定;2例失访,1例死亡。结论:寻常型银屑病合并大疱性类天疱疮临床相对少见,中老年患者居多,糖皮质激素联合免疫抑制剂治疗有效。Objective:To summarize the clinical features and treatment of the patients with psoriasis vulgaris complicated with bullous pemphigoid.Methods:The data of the patients diagnosed as psoriasis vulgaris complicated with bullous pemphigoid in our hospital from January 2016 to February 2018 was analyzed retrospectively.Results:Ten patients with psoriasis vulgaris with bullous pemphigoid were found,including 9 males and 1 female.The median age was(59.90±10.18)years.Psoriasis onset preceded bullous pemphigoid in all the patients.The bullous lesions occurred on the psoriatic lesions in 8 patients and bullous lesions occurred on the normal skin in 2.Nine patients were treated with corticosteroids and/or immunosuppressive agents,and one case was treated with tetracycline combined with niacinamide and narrow band UVB.After an follow-up of 150 to 1065 days,there was no new blister lesions occurred and psoriatic lesions remained stable in seven patients.Two cases were lost to follow-up and one died.Conclusion:Psoriasis vulgaris complicated with bullous pemphigoid was rare and mainly affects the elderly.Corticosteroids combined with immunosuppressants was effective for treating psoriasis vulgaris complicated with bullous pemphigoid.

关 键 词：银屑病 大疱性类天疱疮 临床分析 

分 类 号：R75[医药卫生—皮肤病学与性病学]