小儿支原体肺炎合并肝功损害与心肌功能、CD4+/CD8+的关系及甘草酸苷的效用  

The relationship between liver function damage and myocardial function,CD4+/CD8+ in children with mycoplasma pneumonia,and the effects of glycyrrhizin

作　　者：赵庆鹏[1] 韩广强 赵庆珍 ZHAO Qingpeng;HAN Guangqiang;ZHAO Qingzhen(Department of Paediatrics,the First People′s Hospital of Jining,Jining 272000,China)

机构地区：[1]济宁市第一人民医院儿科

出　　处：《西北药学杂志》2019年第6期818-822,共5页Northwest Pharmaceutical Journal

摘　　要：目的探讨小儿支原体肺炎患者合并肝功损害与心肌功能、CD4+/CD8+的关系以及甘草酸苷的效用,为小儿支原体肺炎患者合并肝功损害的临床诊治提供参考。方法选择医院收治的236例小儿支原体肺炎患者作为研究对象,根据患者是否合并肝功能损害将其分为肺炎组(n=106例)和肝功损害组(n=130),比较2组患者的外周血T淋巴细胞亚群、细胞因子以及心肌酶相关指标水平的差异。另将肝功损害组患者随机分为观察组和对照组,各65例,对照组给予常规治疗,观察组在对照组治疗的基础上联用复方甘草酸苷注射液,比较2组患者治疗前后的肝功能变化,分析2组患者治疗后的临床疗效。结果与肺炎组相比,肝功损害组患者血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、肌酸激酶同工酶MB(CK-MB),血清肌酸激酶(CK)和CD8+水平较高,CD3+、CD4+以及CD4+/CD8+水平较低,差异具有统计学意义(P<0.05)。治疗后,观察组和对照组2组患者的血清丙氨酸氨基转移酶(ALT),总胆红素(TBIL)和谷氨酸转移酶(GGT)水平均明显降低,而观察组患者上述指标降低更显著(P<0.05)。观察组患者的治疗有效率为96.92%,明显高于对照组的73.85%,差异有统计学意义(P<0.05)。结论小儿支原体肺炎患者合并肝功损害与外周血细胞因子、T淋巴细胞亚群以及心肌功能存在一定的相关性,联用甘草酸苷可以明显改善其肝功能,加快肺炎的好转。Objective To investigate the relationship between liver function damage and myocardial function,CD4+/CD8+in children with mycoplasma pneumonia,and the effects of glycyrrhizin,so as to provide reference for the diagnosis and treatment of liver dysfunction in patients with mycoplasma pneumonia.Methods A total of 236 patients with mycoplasma pneumonia in the hospital were selected as study subjects.Patients were divided into pneumonia group(n=106)and liver function impairment group according to whether they were associated with liver function impairment(n=130).The differences in peripheral blood T-lymphocyte subsets,cytokines,and myocardial enzyme related indicators were compared between the 2 groups.In addition,patients with liver function impairment were randomly divided into observation group and control group,with 65 cases in each group.The control group was given routine treatment,while the observation group was treated with Compound Glycyrrhizin Injections on the basis of routine treatment.The liver function changes before and after treatment were compared and analyzed between the 2 groups.Results Compared with the pneumonia group,the levels of serum IL-6,IL-8,IL-10,TNF-α,LDH,AST,CK-MB,CK and CD8+were higher in patients with liver function impairment group.The levels of CD3+,CD4+and CD4+/CD8+were low and the difference was statistically significant(P<0.05).After treatment,serum ALT,TBIL and GGT levels were significantly lower in the observation group and the control group,while the above-mentioned indicators decreased more significantly in the observation group(P<0.05).The effective rate of observation in patients in the observation group was 96.92%,which was significantly higher than that in the control group(73.85%).The difference was statistically significant(P<0.05).Conclusion There is a certain correlation between liver function damage and peripheral blood cytokines,T lymphocyte subsets,and myocardial function in patients with mycoplasma pneumonia in children.After giving glycyrrhizin,the liver function

关 键 词：小儿支原体肺炎 肝功损害 心肌功能 CD4+/CD8+ 复方甘草酸苷注射液 

分 类 号：R985[医药卫生—药品]