联合药物治疗方案对盐敏感性高血压与非盐敏感性高血压在预防冠心病中的疗效评价  

Evaluation on curative effects of combined drug therapy regimen in the prevention of coronary heart disease for salt sensitive hypertension and non-salt sensitive hypertension

作　　者：姚华丽 YAO Huali(Jieyang People’s Hospital,Jieyang 522000,China)

机构地区：[1]广东省揭阳市人民医院

出　　处：《中国医药科学》2019年第19期82-85,共4页China Medicine And Pharmacy

摘　　要：目的研究培哚普利联合氨氯地平、吲达帕胺缓释片治疗方案对盐敏感性高血压与非盐敏感性高血压在预防冠心病中的疗效。方法选取我院2015年1月~2016年12月初治的160例轻中度高血压住院患者为研究对象,探究治疗后24h动态血压[收缩压(SBP)、舒张压(DBP)]、糖化血红蛋白(HbA1c)、血尿酸(SUA)、尿白蛋白(MA)/肌酐(Cr)比值下降水平、血脂水平[TC(总胆固醇)、TG(甘油三酯)、LDL-C(低密度脂蛋白)、HDL-C(高密度脂蛋白)]。结果对于SS组患者,观察二组各临床指标的变异性以及下降水平均高于观察一组(P<0.05)。对于NSS组,对照一组各临床指标的变异性以及下降水平均高于对照二组(P<0.05)。限盐饮食后,两种联合治疗方案对盐敏感性高血压者在控制冠心病高危因素方面比较,差异无统计学意义(P>0.05)。结论对于不同类型的患者,应采用不同的联合治疗方案,并进行限盐。Objective To study curative effects of perindopril combined with amlodipine and indapamide sustained release tablet in the prevention of coronary heart disease for salt sensitive hypertension and non-salt sensitive hypertension.Methods 160 hospitalized patients with mild-to-moderate hypertension who were diagnosed from January 2015 to December 2016 were selected as research objects.24-hour post-treatment ambulatory blood pressure of 24 hours after treatment[systolic blood pressure(SBP),diastolic blood pressure(DBP)],glycosylated hemoglobin(HbA1c),blood uric acid(SUA),decrease of urinary albumin(MA)/creatinine(Cr)ratio,blood lipid levels[TC(total cholesterol),TG(triglyceride),LDL-C(low density lipoprotein),HDL-C(high density lipoprotein)]were explored.Results For patients in SS group,the variability and decline level of all clinical indexes in the observation two group were higher than those in the observation one group(P<0.05).For the NSS group,the variability and decline level of each clinical index in the control group were higher than those in the control two group(P<0.05).After salt restricted diet,there was no significant difference in the control of risk factors of coronary heart disease in patients with salt-sensitive hypertension between combined treatment regimens(P>0.05).Conclusion For different types of patients,different combined treatment regimens should be adopted and salt should be limited.

关 键 词：培哚普利 吲达帕胺缓释片 氨氯地平 盐敏感性高血压 非盐敏感性高血压 

分 类 号：R259[医药卫生—中西医结合]