黏膜病变及幽门螺杆菌感染对胃泌素族胃肠激素表达的影响研究  

Influence of gastric mucosal lesion and Helicobacter pylori infection on the expression of gastrin family gastrointestinal hormones

作　　者：窦广仙 孙光斌 贾惠娟[1] 王萍 张金娜 DOU Guang-xian;SUN Guang-bin;JIA Hui-juan;WANG Ping;ZHANG Jin-na(Tianjin Fifth Central Hospital,Tianjin 300450,China)

机构地区：[1]天津市第五中心医院中心内镜室

出　　处：《中华医院感染学杂志》2019年第20期3121-3124,3165,共5页Chinese Journal of Nosocomiology

基　　金：滨海新区卫生局基金资助项目(2013BWKY0310)

摘　　要：目的观察胃镜下黏膜病变合并幽门螺杆菌(Helicobacter pylori,Hp)感染对胃泌素族胃肠激素表达的影响。方法选取2016年8月-2017年11月于天津市第五中心医院就诊的胃镜下黏膜病变合并Hp感染患者90例为A组,胃镜下黏膜病变患者90例为B组,Hp感染患者90例为C组,另选取同期的90名体检健康者为D组。比较研究对象餐前及餐后胃泌素族胃肠激素[胃动素(motilin,MTL)及血清胃泌素(gastrin,GAS)]表达水平,并比较A组及B组不同胃黏膜病变积分、A组及C组中不同Hp感染情况指标的表达水平。结果A、B及C组患者的餐前血清MTL及GAS水平分别为(283.45±31.63)ng/L及(118.68±12.56)ng/L、(202.54±28.98)ng/L及(84.61±7.45)ng/L、(199.32±28.42)ng/L及(82.25±7.10)ng/L,餐后血清MTL及GAS水平分别为(320.44±35.67)ng/L及(126.84±14.38)ng/L、(215.35±30.68)ng/L及(88.20±7.93)ng/L、(213.56±29.93)ng/L及(86.15±7.75)ng/L,均高于D组的(165.65±22.35)ng/L及(60.12±5.66)ng/L、(182.54±23.72)ng/L及(65.45±6.13)ng/L,A组高于B组及C组;A组及B组不同胃黏膜病变积分、A组及C组不同Hp感染情况患者表达水平比较,差异有统计学意义(P<0.05)。结论胃黏膜病变合并Hp感染可导致胃泌素族胃肠激素表达水平升高,且胃黏膜积分越高合并Hp感染患者的表达水平相对更高。OBJECTIVE To observe the influence of gastric mucosal lesion and Helicobacter pylori(Hp)infection on the expression of gastrin family gastrointestinal hormones.METHODS 90patients with gastric mucosal lesion and Hp infection from Aug.2016to Nov.2017were selected as group A,90patients with mucosal lesion under gastroscope were selected as group B,90patients with Hp infection were selected as group C,90healthy persons who underwent physical examination at the same time were selected as group D.Then the expression levels of gastrin family gastrointestinal hormones[(motilin,MTL)and(gastrin,GAS)]before and after meal of the four groups were compared,and the expression levels of group A and group B with different mucosal lesion scores,group A and group C with different Hp infection situation were compared as well.RESULTS The serum MTL and GAS of group A,group B and group C before meal were respectively(283.45±31.63)ng/L and(118.68±12.56)ng/L,(202.54±28.98)ng/L and(84.61±7.45)ng/L,(199.32±28.42)ng/L and(82.25±7.10)ng/L,the serum MTL and GAS after meal were respectively(320.44±35.67)ng/L and(126.84±14.38)ng/L,(215.35±30.68)ng/L and(88.20±7.93)ng/L,(213.56±29.93)ng/L and(86.15±7.75)ng/L,and they were all higher than(165.65±22.35)ng/L and(60.12±5.66)ng/L,(182.54±23.72)ng/L and(65.45±6.13)ng/L of group D,the results of group A were all higher than those of group B and group C;the expression levels of group A and group B with different mucosal lesion scores,group A and group C with different Hp infection situation were compared,and the differences were statistically significant(P<0.05).CONCLUSIONThe expression of gastrin family gastrointestinal hormones in patients with gastric mucosal lesion and Hp infection are increased,and the levels of patients with higher mucosal lesion score and Hp infection situation are relatively higher.

关 键 词：胃黏膜病变 幽门螺杆菌感染 胃泌素族胃肠激素 

分 类 号：R378[医药卫生—病原生物学]