野木瓜总皂苷在小鼠大脑皮层中瞬时镇痛效果研究  

Transient Analgesic Effect of TSS in Mouse Cerebral Cortex

作　　者：周仲燕 荣伊 Zhou Zhongyan;Rong Yi(Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis&Treatment,Biomedical EngineeringCollege,South-Central University for Nationalities,Wuhan,Hubei,430074,China)

机构地区：[1]中南民族大学生物医学工程学院医学信息分析及肿瘤诊疗湖北省重点实验室

出　　处：《绿色科技》2019年第20期147-148,158,共3页Journal of Green Science and Technology

摘　　要：指出了野木瓜总皂苷是一种用于消炎镇痛的传统中药。为了研究野木瓜总皂苷的瞬时镇痛效果,选取体外培养成熟的小鼠大脑皮层神经元,采用全细胞膜片钳技术,记录了不同浓度野木瓜总皂苷对细胞mEPSC和mIPSC的影响。发现在瞬时改变野木瓜总皂苷浓度的情况下,记录到mEPSC和mIPSC的频率和幅值均没有显著变化。结果表明:野木瓜总皂苷在小鼠大脑皮层中的镇痛效果不是瞬时产生的。Triterpenoid saponins from Stauntonia chinensis(TSS,for short)is a traditional Chinese medicine for anti-inflammatory and analgesic.In order to study the transient analgesic effect of TSS,the mature mouse cerebral cortex neurons were cultured in vitro.Whole-cell patch clamp technique was used to record mEPSC and mIPSC in different concentrations of TSS.It was found that the frequency and amplitude recorded to mEPSC and mIPSC did not change significantly in the case of transiently changing the TSS concentration.This indicates that the analgesic effect of TSS in the mouse cerebral cortex is not transient.

关 键 词：野木瓜总皂苷 传统中药 大脑皮层神经元 

分 类 号：R285[医药卫生—中药学]