儿童腺病毒肺炎免疫学特点及免疫学治疗方法  

Immunological characteristics and treatment of pediatric adenovirus pneumonia

作　　者：宋文良[1] 刘春峰[1] Song Wenliang;Liu Chunfeng(Pediatric Intensive Care Unit,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院儿科重症监护病房,沈阳110004

出　　处：《中国小儿急救医学》2019年第10期746-751,共6页Chinese Pediatric Emergency Medicine

基　　金：辽宁省中央引导地方科技发展专项(2018108001);辽宁省重点研发计划指导计划项目(2017225003)。

摘　　要：腺病毒是儿童呼吸道感染的重要原因,容易引起重症肺炎.而腺病毒感染后又会对机体免疫系统造成损伤,不仅会引起T、B细胞数量及功能的降低,Th1/Th2比例失衡,而且会造成促炎及抗炎细胞因子的失衡,进一步造成机体免疫功能紊乱,严重者可导致重症脓毒症、甚至多脏器功能损伤.本文通过探讨腺病毒感染的免疫学发病机制,为治疗腺病毒肺炎提供思路.Adenovirus is a common cause of respiratory infection in children and can cause severe pneumonia.Adenovirus can also cause damage to immune system.It can cause decrease in T and B cell number and function,imbalance of Thl/Th2 cell proportion,but also can cause imbalance of proinflammatory cytokines and anti-inflammatory cytokines,further leading to dysfunction of immune system,with severe complications such as severe sepsis and multiple organ and system dysfunction.In this paper we will discuss immune pathogenesis of adenovirus infection and provide suggestion for treatment of adenovirus pneumonia.

关 键 词：腺病毒肺炎 儿童 免疫学 治疗 

分 类 号：R72[医药卫生—儿科]