An Alternative Synthesis and Crystal Structure Characterization of Nutrient Fortifier N-(1-(Phenylacetyl)-L-prolyl) Glycine Ethyl Ester  

作　　者：李艳如 崔建兰 于思源 钟丛杉 王宁 王晓 

机构地区：[1]School of Chemical Engineering and Technology, North University of China

出　　处：《Chinese Journal of Structural Chemistry》2019年第10期1727-1734,1611,共9页结构化学（英文）

摘　　要：A nutritional fortifier N-(1-(phenylacetyl)-L-prolyl)glycine ethyl ester(4)was successfully synthesized through two synthetic schemes and characterized by IR,^1H-NMR,^13C-NMR,elemental analysis and X-ray single-crystal diffraction.The intermediate N-phenylacetyl-L-proline(2)was synthesized by the solid-liquid reaction of L-proline and phenylacetyl chloride directly.Compound 2(C13 H15 NO3,Mr=233.26)belongs to the orthorhombic system,space group P212121 with a=8.9468(3),b=9.3190(3),c=14.0453(4)A,V=1171.03(6)A^3,Z=4,Dc=1.323 g/cm^3,μ=0.773 mm^-1,F(000)=496.0,the final R=0.0313 and wR=0.0797 for all data.Compound 4(C17 H22 N2 O4,Mr=318.36)is of orthorhombic system,space group P212121 with a=6.5831(2),b=8.5536(2),c=28.9138(9)A,V=1628.11(8)A^3,Z=4,Dc=1.299 g/cm3,μ=0.763 mm-1,F(000)=680.0,the final R=0.0353 and wR=0.0816 for all data.A nutritional fortifier N-（1-（phenylacetyl）-L-prolyl） glycine ethyl ester（4） was successfully synthesized through two synthetic schemes and characterized by IR, 1H-NMR, 13C-NMR, elemental analysis and X-ray single-crystal diffraction. The intermediate N-phenylacetyl-L-proline（2） was synthesized by the solid-liquid reaction of L-proline and phenylacetyl chloride directly. Compound 2（C13 H15 NO3, Mr = 233.26） belongs to the orthorhombic system, space group P212121 with a = 8.9468（3）, b = 9.3190（3）, c = 14.0453（4） ?, V = 1171.03（6） ?3, Z = 4, Dc = 1.323 g/cm3, μ = 0.773 mm-1, F（000） = 496.0, the final R = 0.0313 and wR = 0.0797 for all data. Compound 4（C17 H22 N2 O4, Mr = 318.36） is of orthorhombic system, space group P212121 with a = 6.5831（2）, b = 8.5536（2）, c = 28.9138（9） ?, V = 1628.11（8） ?3, Z = 4, Dc = 1.299 g/cm3, μ = 0.763 mm-1, F（000） = 680.0, the final R = 0.0353 and wR = 0.0816 for all data.

关 键 词：N-(1-(phenylacetyl)-L-prolyl) GLYCINE ETHYL ESTER N-phenylacetyl-L-proline dicyclohexyl-carbodiimide crystal structure GLYCINE ETHYL ESTER hydrochloride 

分 类 号：O62[理学—有机化学]