两种卡前列素氨丁三醇对预防剖宫产后出血的疗效与安全性研究  

A comparison of domestic carboprostversus imported carboprost in prevention of postpartum hemorrhage after caesarean delivery

作　　者：黄亭 朱锦明[2] 石祥奎 HUANG Ting;ZHU Jin-ming;SHI Xiang-kui(Pharmaceutical Affairs,Xuzhou Maternity and Child Health Care Hospital,Xuzhou 221009,Jiangsu,China)

机构地区：[1]徐州市妇幼保健院药事科,江苏徐州221009 [2]徐州市妇幼保健院产科

出　　处：《中国校医》2019年第10期729-731,786,共4页Chinese Journal of School Doctor

基　　金：徐州市临床药学课题(XZZDY1607)

摘　　要：目的评估国产与进口卡前列素氨丁三醇预防剖宫产产妇产后出血的临床疗效与安全性。方法选取徐州市妇幼保健院2017年3月-2018年3月收治的374例剖宫产产妇,分为研究组和对照组,研究组给予国产卡前列素氨丁三醇(188例),对照组给予进口卡前列素氨丁三醇(186例)。比较2组产妇术中出血量、术后血红蛋白下降值和不良反应发生率。同时对单一合并症或并发症产妇进行亚组分析。结果研究组术中出血量为(382.45±79.17)mL,对照组术中出血量为(369.09±67.57)mL,2组比较差异无统计学意义(P>0.05)。研究组术后血红蛋白下降值为(11.51±7.33)g·L-1,对照组术后血红蛋白下降值为(11.33±7.57)g·L-1,2组比较差异无统计学意义(P>0.05)。合并瘢痕子宫产妇出血量,研究组为(379.72±71.76)mL,对照组为(355.40±57.95)mL,2组比较差异具有统计学意义(P<0.05)。其他具有单一合并症或并发症(妊娠期糖尿病、妊娠期甲状腺功能减退、贫血、羊水过多、巨大儿)产妇出血量,2组比较差异无统计学意义(P>0.05)。术后血红蛋白下降值比较,2组差异无统计学意义(P>0.05)。研究组恶心和呕吐发生率明显高于对照组,差异具有统计学意义(P>0.05)。结论国产与进口卡前列氨丁三醇对预防剖宫产产妇产后出血临床疗效没有明显差异,但国产卡前列素氨丁三醇恶心和呕吐的发生率高于进口。Objective To evaluate the curative effect and safety of domestic carboprostversus imported carboprost in the prevention of postpartum hemorrhage after cesarean delivery. Methods The clinical data of 374 pregnant women recruited inXuzhou Maternity and Child Health Care Hospital from March 2017 to March 2018 were collected and retrospectively analyzed. Then they were divided into two groups according to making medicine in the operation. A trial group including 188 cases and a control groupincluding 186 cases were given domestic carboprostand imported carboprost, respectively.The intraoperative blood losses, hemoglobin levels and incidences of adverse effects were observed and compared between the two groups. Simultaneously, the subgroup analysis was performed on thepregnant women with single or multiple complications. Results The average amount of bleeding in the trial group was(382.45±79.17) m L, and the average amount of bleeding in the control group was(369.09±67.57) mL, and there was no significant difference between two groups(P>0.05). After the surgery, the average decrease value of hemoglobin in the trial group was(11.51±7.33) g/·L-1, and the average decrease value of hemoglobin in the control group was(11.33±7.57) g·L-1, and there was no significant difference between two groups(P>0.05). The average amount of bleeding of the scarred uterus puerperae in the trial group was(379.72±71.76) mL, and the average amount of bleeding of the scarred uterus puerperae in the control group was(355.40±57.95) mL, and there was a significant difference between two groups(P<0.05). There was no significant difference between the two groups in the average amount of bleeding of the puerperae with single or multiple complications(gestational diabetes, gestational hypothyroidism,anemia, polyhydramnios, and fetal macrosomia)(P>0.05). There was no significant difference between the two groups in the average decrease value of hemoglobin after the surgery(P>0.05). The occurrence rates of vomiting and nausea in the trial group

关 键 词：卡前列素氨丁三醇 剖宫产 产后出血 

分 类 号：R714.461[医药卫生—妇产科学]