重组犬腺病毒2型疫苗的研制现状  

The status in the research of recombinant Canine Adenovirus type 2 vaccine

作　　者：李文桂[1] 陈雅棠[1] LI Wengui;CHEN Yatang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所

出　　处：《国外医学（医学地理分册）》2019年第4期339-342,353,共5页Foreign Medical Sciences：Section of Medgeography

基　　金：国家自然科学基金资助项目(No.30801052、No.30671835、No.30500423和No.30200239)

摘　　要：犬腺病毒2型引起的传染性喉气管炎是一种常见的动物传染病。犬腺病毒2型可诱导感染的宿主产生细胞、体液和黏膜免疫应答,可通过分子生物学技术改造为理想的疫苗载体,从而表达寄生虫和病毒的多种蛋白。这些病原体包括刚地弓形虫、犬细小病毒、猫瘟病毒、犬瘟热病毒、狂犬病毒、犬冠状病毒、汉城病毒和猪繁殖与呼吸综合征病毒等,本文拟就这方面的研制现状进行阐述。Infectious laryngotracheitis caused by Canine Adenovirus type 2 is one type of infectious diseases in animals.this virus may induce the host to produce cellular,humoral and mucosal immune responses,it may become ideal vaccine vector by means of molecular modification and express many proteins of parasite or viruses.These pathogen agents include Toxoplasma gondii,Canine parvovirus,Feline panlenkopenia virus,Canine distemper virus,Rabies virus,Canine coronavirus,Seoul virus,Porcine reproductive and respiratory syndrome virus,and so on.The review outlines the status in the research of recombinant Canine Adenovirus type 2 vaccine.

关 键 词：犬腺病毒2型 疫苗 

分 类 号：R373.1[医药卫生—病原生物学] R392.11[医药卫生—基础医学]