小剂量地塞米松预处理对乳腺癌患者多西紫杉醇化疗致过敏及其他不良反应的影响  

Effects of low-dose dexamethasone pretreatment on allergy and other adverse reactions induced by docetaxel chemotherapy in breast cancer patients

作　　者：滕青华 王延虹[1] 时磊[1] 邢鑫[2] 王丽娟[2] TENG Qinghua;WANG Yanhong;SHI Lei;XING Xin;WANG Lijuan(Department of Pharmacy,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China;Department of Medical Oncology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China)

机构地区：[1]郑州大学第五附属医院药学部,郑州450052l [2]郑州大学第五附属医院肿瘤内科,郑州4500520

出　　处：《癌症进展》2019年第21期2548-2551,共4页Oncology Progress

摘　　要：目的观察小剂量地塞米松预处理对乳腺癌患者多西紫杉醇化疗致过敏及其他不良反应的影响。方法将140例乳腺癌患者按照治疗方法的不同分为观察组(给予小剂量地塞米松预处理)和对照组(未给予地塞米松预处理),每组70例。观察全部患者的化疗情况,比较两组患者的过敏反应和其他不良反应的发生情况及改良疾病累计评分量表(MCIRS)评分情况。结果全部乳腺癌患者均顺利完成了6个周期的化疗。两组患者过敏反应的总发生率和MCIRS评分情况比较,差异均无统计学意义(P﹥0.05)。两组患者的中性粒细胞减少、血小板减少、血红蛋白减少、淋巴细胞减少、恶心呕吐、腹泻、疲劳、水肿或积液、胃部不适的发生率比较,差异均无统计学意义(P﹥0.05);观察组患者的肌肉痛、兴奋或失眠的发生率均明显低于对照组患者(P﹤0.01)。在中性粒细胞减少和疲劳方面,与对照组相比,观察组中MCIRS评分≤14分的患者比例较高(P﹤0.05);在其余不良反应方面,两组患者的MCIRS评分情况比较,差异均无统计学意义(P﹥0.05)。结论对于行多西紫杉醇化疗的乳腺癌患者,给予小剂量地塞米松进行预处理是安全有效的,不但不会增加过敏反应和其他不良反应,还能够降低肌肉痛、兴奋或失眠的发生率。Objective To investigate effects of low-dose dexamethasone pretreatment on allergy and other adverse reactions induced by docetaxel chemotherapy in breast cancer patients.Method According to the respective therapies administered,as many as 140 cases with breast cancer were included in the research as study group(administered with lowdose dexamethasone pretreatment)and control group(without dexamethasone treatment),containing 70 cases in each.The chemotherapy of all patients was observed.The incidence of allergy and other adverse reactions and modified cumulative illness rating scale(MCIRS)scores were compared between the two groups.Result All the breast cancer patients had successfully completed 6 chemotherapy cycles.There was no significant difference in the total incidence of allergic reactions and MCIRS scores between the two groups(P>0.05).There was no significant difference in the incidence of neutropenia,thrombocytopenia,hemoglobinia,lymphocytosis,nausea,vomiting,diarrhea,fatigue,edema or effusion,stomach upset between the two groups(P>0.05);the incidence of myalgia,excitement or insomnia in the observation group was significantly lower than that in the control group(P<0.01).In terms of neutropenia and fatigue,the proportion of patients with MCIRS scores≤14 in the observation group was higher than that in the control group(P<0.05).In terms of other adverse reactions,there was no significant difference in MCIRS scores between the two groups(P>0.05).Conclusion For patients with breast cancer undergoing docetaxel chemotherapy,low-dose dexamethasone pretreatment is safe and effective to not increase the risk of allergy or other adverse reactions,but may reduce the occurrence of myalgia,excitement or insomnia.

关 键 词：乳腺癌 多西紫杉醇 地塞米松 小剂量 预处理 化疗 过敏 

分 类 号：R737.9[医药卫生—肿瘤]