氟伏沙明关键中间体的合成  

Synthesis of the Key Intermediate of Fluvoxamine

作　　者：牛腾 杨天宇[2] 李乔 NIU Teng;YANG Tian-yu;LI Qiao(School of Chemical Engineering,Lanzhou University of Arts and Science,Lanzhou 730000,China;School of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,China)

机构地区：[1]兰州文理学院化工学院,甘肃兰州730000 [2]西北师范大学化学化工学院,甘肃兰州730070

出　　处：《兰州文理学院学报（自然科学版）》2019年第6期45-48,共4页Journal of Lanzhou University of Arts and Science(Natural Sciences)

基　　金：国家自然科学基金(21662030);甘肃省大学生创新创业训练计划项目(201611562021)

摘　　要：报道了以Weinreb酰胺为原料与格氏试剂反应合成氟伏沙明关键中间体5-甲氧基-1-(4-三氟甲基苯基)-1-戊酮.结果表明:该方法具有反应产率高、时间短、操作简单和环境友好等优点.其产物结构经熔点、红外、13 C NMR、1H NMR等确证.The synthesis of 5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone,a key intermediate of fluvoxamine,was reported by the reaction of the Weinreb amide with the Grignard reagent.The result showed that this method had the advantages of short reaction time,good yields,easy operation and being environmentally friendly.The structures were confirmed by m.p.、IR、13 C NMR、1H NMR..

关 键 词：氟伏沙明 Weinreb酰胺 格氏试剂 合成 中间体 

分 类 号：O623.521[理学—有机化学]