血尿酸水平与冠状动脉薄纤维帽粥样硬化斑块的相关性  

Correlation between Serum Uric Acid Level and Thin Fiber Cap Atherosclerotic Plaque in Coronary Arteries

作　　者：王军利[1] 信彬彬[1] WANG Junli;XIN Binbin(Heilongjiang Armed Police Corps Hospital,Harbin,Heilongjiang 150010,China)

机构地区：[1]武警黑龙江省总队医院第一门诊,黑龙江哈尔滨150010

出　　处：《大医生》2019年第12期50-51,共2页Doctor

摘　　要：目的探讨冠心病患者血尿酸水平与薄纤维帽粥样硬化斑块(TCFA)之间的相关性。方法选取武警黑龙江省总队医院心脏中心住院治疗的冠心病患者154例。分析血清尿酸水平与TCFA的关系。结果非TCFA组和TCFA组的血栓比较,差异有统计学意义(P<0.05);两组在斑块侵蚀、滋养血管比较,差异均无统计学意义(P>0.05);两组在斑块破裂和纤维帽厚度方面比较差异有统计学意义(P<0.05);高尿酸组与低尿酸组比较,纤维帽厚度较薄(P<0.05);高尿酸组发生斑块破裂、血栓的概率高于低尿酸组(P<0.05);两组患者在斑块侵蚀、滋养血管比较,差异无统计学意义(P>0.05)。结论冠状动脉TCFA的发生率与患者血尿酸水平升高密切相关,斑块不稳定与血尿酸水平有关。Objective To investigate the correlation between serum uric acid level and thin fiber cap atherosclerotic plaque(TCFA)in patients with coronary heart disease.Methods A total of 154 patients with coronary heart disease who were hospitalized in our heart center were enrolled.The relationship between serum uric acid level and TCFA was analyzed.Results There were significant differences in the thrombus between the non-TCFA group and the TCFA group(P<0.05).There was no statistically significant difference in plaque erosion and nourishing blood vessels(P>0.05).The plaque rupture and fiber cap thickness were statistically significant(P<0.05).The high uric acid group was thinner than the low uric acid group in fiber cap thickness(P<0.05).The probability of plaque rupture and thrombosis was higher in the high uric acid group than that of the low uric acid group(P<0.05).There was no significant difference in plaque erosion and nourishing blood vessels between the two groups(P>0.05).Conclusion The incidence of TCFA is closely associated with the increased levels ofblood uric acid,and plaque instability is associated with blood uric acid level.

关 键 词：冠状动脉粥样硬化性心脏病 薄纤维帽粥样硬化斑块 尿酸 

分 类 号：R54[医药卫生—心血管疾病]