血清可溶性OX40L在原发性高血压合并颈动脉斑块患者中的表达及临床意义  

Expression and Clinical Significance of Serum Soluble OX40L in Patients with Carotid Plaque Associated with Essential Hypertension

作　　者：陈广华[1] 周烨[1] 徐良洁[1] 金鸣锋[1] 严金川[1] 杜荣增[1] CHEN Guanghua;ZHOU Ye;XU Liangjie;JIN Mingfeng;YAN Jinchuan;DU Rongzeng(Department of Cardiology,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu 212001,China)

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《大医生》2019年第8期18-19,80,共3页Doctor

基　　金：江苏大学临床医学专项基金(编号:JDLCZX008)。

摘　　要：目的探讨原发性高血压合并颈动脉粥样硬化斑块患者血清可溶性OX40L(sOX40L)的表达及临床意义。方法选取110例中老年原发性高血压患者进行颈动脉超声检查,根据超声结果以及颈动脉斑块性质分为无斑块组30例、稳定斑块组40例、易损斑块组40例;并应用酶联免疫吸附法(ELISA)法检测各组血清sOX40L、MMP-9水平。结果原发性高血压合并颈动脉斑块组患者血清sOX40L、MMP-9水平显著高于无斑块组(P<0.01)。易损斑块组(C组)血清sOX40L、MMP-9水平也明显高于较稳定斑块组(P<0.01)。三组血清sOX40L水平与MMP-9呈显著正相关(r=0.70,P<0.001)。结论原发性高血压合并颈动脉粥样硬化斑块患者血清sOX40L与MMP-9水平明显升高,且在易损斑块组两者升高更加明显,提示sOX40L水平与颈动脉斑块的稳定性密切相关,sOX40L升高对于高血压合并颈动脉斑块的稳定性有良好的预测作用。Objective To investigate the expression and clinical significance of serum soluble OX40L(sOX40L)in patients with essential hypertension complicated with carotid atherosclerotic plaque.Methods Coronary artery ultrasonography was performed in 110 elderly patients with essential hypertension.According to the ultrasonic results and the nature of carotid plaque,110 cases were divided into 30 cases with no plaque group,40 cases with stable plaque group,and 40 cases with vulnerable plaque group.The levels of sOX40 L and MMP-9 were detected by ELISA.Results The serum levels of sOX40L and MMP-9 were significantly higher in essential hypertension combined with carotid plaque group than in essential hypertension without carotid plaque group(P<0.01).The serum levels of sOX40L and MMP-9 were also significantly higher in the group of essential hypertension combined with vulnerable plaquethan in the stable plaque group(P<0.01).Serum sOX40L levels in three groups were significantly positively correlated with MMP-9(R=0.70,P<0.001).Conclusion The serum levels of sOX40L and MMP-9 in patients with carotid atherosclerotic plaque with essential hypertension were significantly increased,and in the vulnerable plaque group they increased significantly,suggesting that the level of sOX40L was closely related to the stability of carotid plaque.The increase of sOX40L was a good predictor of the stability of carotid plaque associated with hypertension.

关 键 词：OX40配体 基质金属蛋白酶-9 原发性高血压 颈动脉斑块 

分 类 号：R54[医药卫生—心血管疾病]