PLA2R1基因rs4664308位点单核苷酸多态性与特发性膜性肾病易感性的Meta分析  

Meta analysis on single nucleotide polymorphisms of rs4664308 locus in PLA2R1 gene and susceptibility of idiopathic membranous nephropathy

作　　者：谢大星 郭广凤 郑笑 杨淑芬 陆晨 XIE Daxing;GUO Guangfeng;ZHENG Xiao;YANG Shufen;LU Chen(Department of Nephrology,Xinjiang Clinical College of Anhui Medical University/Xinjiang Uygur Autonomous Region People′s Hospital,Urumqi,Xinjiang 830001,China;School of Medicine,Shihezi University,Shihezi,Xinjiang 832000,China)

机构地区：[1]安徽医科大学新疆临床学院/新疆维吾尔自治区人民医院肾病科,乌鲁木齐830001 [2]石河子大学医学院,新疆石河子832000

出　　处：《重庆医学》2019年第21期3704-3708,共5页Chongqing medicine

基　　金：新疆维吾尔自治区自然科学基金项目(2018D01C132)

摘　　要：目的探索PLA2R1基因rs46664308位点单核苷酸多态性与特发性膜性肾病(IMN)易感性的关联。方法通过检索PubMed、Web of science、Medline、中国期刊全文数据库(CNKI)、万方数据库、维普数据库获得PLA2R1基因rs46664308位点与特发性膜性肾病相关的文献,检索时间为建库至2018年12月31日。对纳入的文献进行质量评价后,运用Stata15.0软件进行Meta分析。结果共纳入7篇文献,包含7225例参与者,其中IMN 2508例,健康对照4717例。Meta分析显示:A/G等位基因、显性模式、隐性模式及共显性模型的合并OR(95%CI)分别为2.480(2.100~2.930)、2.920(2.630~3.260)、2.892(2.321~3.602)、4.320(3.450~5.410)、1.640(1.300~2.070),差异有统计学意义(P<0.05)。在隐形模型及共显性模型(AG vs.GG)下欧洲组与IMN的易感性无关(P>0.05),在等位基因及显性模型下亚洲组对IMN易感性高于欧洲组。结论PLA2R1单核苷酸多态性rs4664308是IMN的易感基因位点,等位基因A能增加IMN的易感性,亚洲人群中PLA2R1基因rs4664308位点单核苷酸多态性对IMN的易感性高于欧洲人群。Objective To explore the association between single nucleotide polymorphism(SNP)of rs46664308 locus in PLA2R1 gene and the susceptibility of idiopathic membranous nephropathy(IMN).Methods The literatures related to the rs46664308 locus of PLA2R1 gene and IMN were obtained by retrieving the Pubmed,Web of science,Medline,CNKI,Wanfang and Weipu database.The retrieval time was from their databases establishment to December 31,2018.After conducting the quality evaluation on the included literatures,the meta analysis was performed by using the Stata15.0 software.Results A total of 7 articles were included,including 7225 participants.Among them,there were 2508 cases of IMN and 4717 healthy controls.The meta analysis showed that the A/G allele,the combined OR values and 95%CI of dominant mode,recessive mode and codominant model were 2.480(2.100-2.930),2.920(2.630-3.260),2.892(2.321-3.602),4.320(3.450-5.410)and 1.640(1.300-2.070)respectively,and there were statistically significant differences(P<0.05).In the recessive model and codominant model(AG vs.GG),the European group had no relationship with the susceptibility of IMN(P>0.05).In the allele and dominant models,the Asian group was more susceptible to IMN than the European group.Conclusion PLA2R1 SNP rs4664308 is a susceptibility locus of IMN.Allele A can increase the susceptibility of IMN.The SNP of PLA2R1 gene rs4664308 locus in the Asian population is more susceptible to IMN than the European population.

关 键 词：肾小球肾炎 膜性 基因多态性 PLA2R1 META分析 

分 类 号：R692[医药卫生—泌尿科学]