黄芪甲苷对缺血缺氧性脑血管内皮损伤作用的研究进展  

Research progress on role of Astragaloside Ⅳ in ischemic hypoxic cerebral vascular endothelium injury

作　　者：杜澍金[1] 高维娟[1] DU Shujin;GAO Weijuan(Hebei Key Laboratory of Chinese Medicine Research on Gardio-Cerbrovascular Disease,Hebei University of Chinese Medicine,Shijiazhuang,Hebei 050200,China)

机构地区：[1]河北中医学院河北省心脑血管病中医药防治研究重点实验室

出　　处：《重庆医学》2019年第21期3720-3723,共4页Chongqing medicine

基　　金：国家自然科学基金面上项目(81873180);河北省2019年研究生创新项目(CXZZBS2019156);河北省中医药管理局课题项目(2018111,2017005);河北中医学院青年基金项目(2017001)

摘　　要：黄芪甲苷是中药黄芪的主要活性单体,具有免疫调节、抗炎、抗凋亡、神经保护、血管重构等多种药理作用,临床上常用于治疗缺血性脑血管疾病。大多数脑血管疾病都是由于血管内皮损伤、通透性增加所致,因此积极控制损伤因素,保护血管内皮功能,改善损伤引起的血管屏障的破坏,对脑血管疾病的防治有重要作用。综合近期的研究,就血管内皮的损伤机制及黄芪甲苷对其保护作用进行综述,以期进行进一步研究,并为其在临床脑血管疾病中的应用提供指导。AstragalosideⅣis the primary active monomer of Chinese medicine Astragalus,which has the multiple pharmaceutical actions such as the immune regulation,anti-inflammation,anti-apoptosis,nerve protection,vascular remodeling and so on,and is usually used to treat ischemic cerebrovascular disease.The majority of cerebrovascular diseases are mainly caused by the vascular endothelial injury and permeability increase.Therefore,actively controlling the damage factors,protecting the vascular endothelial function and improving the damage caused vascular barrier destroy have important effects on the prevention and treatment of cerebrovascular diseases.The recent researches were integrated to review the protective effect of astragaloside on vascular endothelial damage and its mechanism,in order to conduct the further research and provide the guidance for its application in clinical cerebrovascular diseases.

关 键 词：黄芪甲苷 内皮 血管 通透性 内皮屏障 

分 类 号：R285.5[医药卫生—中药学]