妊娠胆汁淤积症发病机制的研究进展  

Study on progress in pathogenesis of intrahepatic cholestasis of pregnancy

作　　者：胡珊 熊光武 HU Shan;XIONG Guangwu(Gynecology and Obstetrics Center,Affiliated Third Hospital,Chongqing Medical University,Chongqing 401120,China)

机构地区：[1]重庆医科大学附属第三医院妇产中心

出　　处：《重庆医学》2019年第21期3729-3734,共6页Chongqing medicine

摘　　要：妊娠胆汁淤积症(ICP)是一种妊娠期特发性的胆汁代谢障碍性疾病,与代谢综合征存在着密切的关系,但其发病机制仍然存在很多未知之处。ICP患者血清胆汁酸水平明显升高,进而引起免疫系统的变化,使得原本以Th2偏移为主的免疫反应向Th1反应的方向转化,从而诱发了多种风险。ICP患者发生血糖、血脂代谢紊乱的比例明显升高,这可能是由于胆汁酸与葡萄糖、血脂代谢的共同通路发生了紊乱所致,因此ICP与代谢综合征也存在着密切的关系。Intrahepatic cholestasis of pregnancy(ICP)is an important idiopathic bile metabolism disorder during pregnancy,and closely related to metabolic syndrome,but its pathogenesis has not been well understood.The level of serum bile acid increased significantly,thus leads to the immune system change,which makes the immune reactions dominated by Th2 shift to the direction of Th1 reaction,thus induces multiple risks.The proportion of the patients suffering from the metabolic disorders of blood sugar and blood lipid significantly increases,which may be caused by the disorder occurrence of common pathway of bile acid with glucose and blood lipid metabolism.Therefore,ICP has the close relationship with metabolic syndrome.

关 键 词：胆汁淤积 妊娠并发症 胆汁酸 T淋巴细胞 代谢综合征 

分 类 号：R714.7[医药卫生—妇产科学]