儿童难治性肺炎支原体肺炎血清中IL-6、IL-10及免疫功能的变化及临床意义  

Changes and clinical significance of immune function and serum IL-6 and IL-10 of children with refractory mycoplasma pneumoniae pneumonia

作　　者：周晓飞 过毅[1] ZHOU Xiao-fei;GUO Yi(Department of Pediatrics,Wuxi Second People,s Hospital Affiliated to Nanjing Medical University,Wuxi 214000,Jiangsu Province,China)

机构地区：[1]南京医科大学附属无锡第二人民医院儿科

出　　处：《中国优生与遗传杂志》2019年第10期1270-1272,1275,共4页Chinese Journal of Birth Health & Heredity

基　　金：无锡市卫生计生委妇幼健康科研课题，编号FYKY201602

摘　　要：目的探讨难治性肺炎支原体肺炎患儿血清中IL-6、IL-10、免疫球蛋白及T细胞亚群水平变化及临床意义。方法选取2016年9月至2018年12月在南京医科大学附属无锡第二人民医院儿科住院的108例普通肺炎支原体肺炎患儿和42例难治性肺炎支原体肺炎患儿,比较其血清学指标变化(IL-6、IL-10、IgG、IgM、IgA、CD4/CD8等)。结果难治性支原体肺炎组患儿急性期、亚急性期血清IL-6、IL-10水平较恢复期及普通支原体肺炎对照组明显升高,CD3、CD4、CD4/CD8水平较普通支原体肺炎对照组明显下降,差异有统计学意义(P<0.05)。血清IgG、IgM、IgA比较无明显统计学差异。结论难治性肺炎支原体肺炎患儿急性期、亚急性期及恢复期均存在体液及细胞免疫功能紊乱及炎症因子表达异常,炎症因子变化可作为早期识别依据,同时早期联合使用糖皮质激素及免疫调节剂可缩短病程,提高治愈率。Objective:To determine the immune function and level of inflammation factors IL-6 and IL-10 of children with refractory mycoplasma pneumoniae pneumonia(RMPP),investigate its clinical significance.Methods:Forty-two RMPP children in our hospital from September 2016 to December 2018 were detected in comparison with general Mycoplasma pneumoniae pneumonia(GMPP)children.The level of immunoglobulins such as IgM、IgG and IgA,cell factor(IL-6、IL-10)and T cell subsets(CD3、CD4、CD8)were determined.Results:The IL-6 and IL-10 levels of children in RMPP group were significant increased in acute and subacute stage,and decreased in recovery stage,on the contrary.Meanwhile,they were much higher than the GMPP group.In all stages,the percentage of CD3,CD4 and the ratio of CD4/CD8 T cells of the RMPP group were significantly lower than those of GMPP group.There was no significant change between immunoglobulins IgM、IgG and IgA in all stages.Conclusion:There were immune dysfunction and inflammation factors abnormal expression in RMMP children in acute、subacute and recovery stage.The levels of serum IL-6,IL-10 are significantly increased,which is helpful for the early identification of RMPP.The employment of immune-regulation therapy can shorten the length of disease and improve its recovery rate.

关 键 词：儿童 支原体肺炎 难治性 免疫功能 

分 类 号：R725[医药卫生—儿科]