首诊孤独症患儿功能性磁共振成像脑自发活动低频振幅图和低频振幅分数图上的区域性异常改变研究  

Study on Rregionally anomalous changes of ALFF map and f ALFF map of spontaneous activity of brain in children with autism by fMRI

作　　者：陈晓亮 王铁岩[1] 朱颖[1] 杨春鸿[1] 陈静[1] 张岩 CHEN Xiao-Liang;WANG Tie-Yan;ZHU Ying(Pediatric Department,The Second Affiliated Hospital of Qiqihar Medical University,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院附属第二医院儿科,黑龙江齐齐哈尔161006 [2]佳木斯医学院临床医学院神经内科,黑龙江佳木斯154000

出　　处：《中国医学装备》2019年第11期40-44,共5页China Medical Equipment

基　　金：黑龙江省卫生计生委科研课题(2018146)“功能性磁共振成像对脑结构异常改变的诊断研究的磁共振特点研究”;齐齐哈尔市科学技术项目(20170712)“小儿神经系统疑难疾病的诊治研究”

摘　　要：目的:探讨孤独症首次功能性磁共振成像(fMRI)诊断儿童脑自发活动低频振幅分数(fALFF)图及低频振幅(ALFF)图上的区域性异常变化研究。方法:选择医院收治的40例孤独症首诊儿童,并将其纳入观察组,将同期体检的40名健康儿童纳入健康对照组,两组均在静息状态下应用3.0T TX型超导磁共振扫描仪进行梯度回波序列采集血氧依赖水平(BOLD)的脑功能成像数据,予以空间标准化、校正头动及预处理时间校正,6 mm高斯核平滑运算,采用REST脑功能软件处理数据,得到两组的fALFF图和ALFF图,比较两组的图像差别。结果:观察组患儿右侧颞回、颞极中部ALFF值显著低于健康对照组,差异有统计学意义(t=11.9085,P<0.05);观察组患儿的左侧颞回、梭状回枕中回、右侧颞回、右侧颞极中部、颞中以及下回的fALFF图值显著低于健康对照组,差异均有统计学意义(t=17.1685,t=5.9370,t=6.738;P<0.05);观察组患儿双侧小脑内侧、小脑蚯部及脑干部的fALFF图值显著高于健康对照组,差异有统计学意义(t=5.2935,P<0.05)。结论:fMRI静息状态下的fALFF图和ALFF图可发现孤独症患儿的多脑区功能异常变化,可能与孤独症的核心症状密切相关,可作为评估低龄儿童脑功能发育的重要方式。Objective:To explore the regionally anomalous changes of fractional amplitude of low-frequency fluctuation(f ALFF)map and amplitude of low-frequency fluctuation(ALFF)map of functional magnetic resonance imaging(fMRI)in diagnosing spontaneous activities of the brains of children with autism.Methods:40 children with autism who were initially confirmed in our hospital were divided into observation group,while 40 healthy children who received physical examination at the same period were divided into health control group.Under the quiescent condition of two groups,the blood oxygen level dependent(BOLD)-brain function imaging was collected by 32-channel coils and gradient-echo sequence of 3.0 T TX superconductive magnetic resonance scanner.And the imaging data were implemented spatial normalization,realignment,pretreatment time correction and 6 mm Gaussian kernel smoothing operation.REST brainfunction software was adopted to process data,and then the fALFF map and ALFF map of two groups were obtained.The differences of images between two groups were compared.Results:ALFF value of right temporal gyrus and middle temporal pole of observation group was significantly lower than that of control group(t=11.9085,P<0.05).And fALFF values of"left temporal gyrus and fusiform gyrus","right temporal gyrus","middle part of right temporal pole,middle temporal gyrus and inferior temporal gyrus"of observation group were significantly lower than those of control group(t=17.1685,t=5.9370,t=6.738,P<0.05).fALFF values of"inner side of bilateral epencephalon,cerebellar vermis and brain stem"inof the observation group wasere significantly higher than that of control group(t=5.2935,P<0.05).Conclusion:Under the quiescent condition,fALFF map and ALFF map of fMRI can find anomalous changes of the function of multi-encephalic region of children with autism.And these changes might be closely related with kernel symptom of autism,and they can be used as important mode to assess the growth of brain function of young children.

关 键 词：脑功能状态 低频振幅分数图 低频振幅图 孤独症患儿 

分 类 号：R445.2[医药卫生—影像医学与核医学]