斑马鱼定向筛选在水体化学风险因子鉴别中的应用  

APPLICATION OF TARGET SCREENING IN IDENTIFICATION OF POISONOUS CHEMICAL FACTORS IN AQUATIC ENVIRONMENT

作　　者：王申 杨方星[1] WANG Shen;YANG Fang-Xing(Institute of Environmental Health,College of Environmental Resource Science,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学环境与资源学院环境健康研究所

出　　处：《水生生物学报》2019年第6期1280-1289,共10页Acta Hydrobiologica Sinica

基　　金：国家自然科学基金面上项目(21677126)资助~~

摘　　要：研究采集了我国东部某医药产业基地河流的7个水体样品,经斑马鱼(Zebrafish,Danio rerio)暴露实验后,各暴露组斑马鱼均出现了不同程度的死亡。为了揭示样品中影响水环境健康风险的化学毒性因子,采用基于248种标准化合物的定向筛选方法,在水体样品中共鉴定出24种化合物,其中包括米氮平、地氯雷他定等17种药物。这些化合物在水体中的浓度水平与斑马鱼死亡率均不呈正相关。研究结果表明,鉴定出的药物组成不是该河流水体健康风险的主要因子。Exposure to water samples collected from a river located in a pharmaceutical industry park in Eastern China resulted in some extent of death for zebrafish.A target screening method involving 248 compounds was employed to reveal the main poisonous chemical factors in these water samples.Twenty four compounds were identified including 17 pharmaceuticals such as mirtazapine and desloratadine.However,no positive relationship was observed between the residual levels of these compounds and death rates of zebrafish.The results suggest that the compounds identified in the water samples were not the main poisonous contributors for the aquatic health risk in the river.

关 键 词：定向筛选 健康风险 毒性因子 斑马鱼 液质联用 

分 类 号：X522[环境科学与工程—环境工程]