2,6-二氟苯腈的合成  

Synthesis of 2,6-Difluorobenzenitrile

作　　者：李瑞军[1] 冯冰冰 温兴锋 孙建仁 Li Ruijun;Feng Bingbing;Wen Xingfeng;Sun Jianren(Zhengzhou University,College of Chemistry and Molecular Engineering,He’nan,450000;Zhejiang Huaji Biotechnology Co.Ltd.,Zhejiang,325024)

机构地区：[1]郑州大学化学与分子工程学院,河南450000 [2]浙江华基生物技术有限公司,浙江325024

出　　处：《当代化工研究》2019年第14期109-111,共3页Modern Chemical Research

摘　　要：以2,6-二氯苯腈为原料,环丁砜为溶剂,通过与氟化钾进行氟代反应制得2,6-二氟苯腈,含量大于99%,收率90%.该工艺简便,氟代反应不使用催化剂,生产成本低、收率高,适合工业化生产.2,6-Difluorobenzenitrile was synthesized from 2,6-dichlorobenzenitrile by fluorination reaction with potassium fluoride in sulfolane as solvent.The content of 2,6-difluorobenzenitrile was more than 99%and the yield was 90%.The synthesis process is simple with lowwer cost,higher yield and without catalyst.The process is suitable for industrial production.

关 键 词：氟代反应 氟化钾 2 6-二氟苯腈 

分 类 号：TQ2[化学工程—有机化工]