抗菌肽cathelicidins在感染免疫中作用的研究进展  

Progress of antimicrobial peptides cathelicidins in infection and immunology

作　　者：刘宽 陈涛[1] 田李星[2] 王静 唐欣 梁华平[1,2] Liu Kuan;Chen Tao;Tian Lixing;Wang Jing;Tang Xin;Liang Huaping(Department of Intensive Care Unit,the Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou,China;State Key Laboratory of Trauma,Burns and Combined Injury,Research Institute of Field Surgery,Daping Hospital,Army Medical University,Chongqing 400042,China)

机构地区：[1]遵义医学院附属医院重症医学科,563003 [2]陆军军医大学大坪医院野战外科研究所,创伤烧伤与复合伤国家重点实验室,重庆400042

出　　处：《中华危重病急救医学》2019年第9期1163-1166,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(81671906)。

摘　　要：感染是临床患者主要死亡原因之一,多重耐药性导致传统抗菌药物治疗无效。因此,开发新型抗感染药物势在必行。抗菌肽cathelicidins是多种生物体内的阳离子宿主防御肽,体内外研究均证实该抗菌肽家族不仅表现出广谱抗菌活性和对耐药菌高敏感性的特点,而且对机体免疫应答具有良好的指导作用。本文归纳了近几年抗菌肽cathelicidins的相关研究,重点突出了该抗菌肽家族在杀菌、抗炎、调节趋化和吞噬方面的研究成果,为感染相关疾病的治疗提供新思路。Infection is one of the main causes of death in clinical patients,and multi-drug resistance leads to ineffective treatment with conventional antibiotics.Therefore,it is imperative to develop new anti-infective drugs.Antimicrobial peptides cathelicidins are cationic host defense peptides found in many organisms.It has been demonstrated by in vivo and in vitro studies that antimicrobial peptides cathelicidins not only show broad-spectrum antibacterial activity and high sensitivity to drug-resistant bacteria,but also have a good guiding effect on the immune response.This paper summarizes the reports of antimicrobial peptides cathelicidins in recent years,highlighting their research achievements in antibiosis,anti-inflammatory,chemotaxis regulation and phagocytosis,providing new ideas for the treatment of infection-related diseases.

关 键 词：抗菌肽cathelicidins 感染 免疫调节 

分 类 号：S85[农业科学—兽医学]