2016年西安市疱疹性咽峡炎的流行特征和病原学分析  

Epidemiological characteristics and etiology of herpangina cases in Xi’an,2016

作　　者：薛泽润 吴瑞[1] 邓慧玲[2] 张芬 黄银娟[1] 陈海龙[1] 韩月雯 杨玉捷 邓杨妮 马超锋[1] Xue Zerun;Wu Rui;Deng Huiling;Zhang Fen;Huang Yinjuan;Chen Hailong;Han Yuewen;Yang Yujie;Deng Yangni;Ma Chaofeng(Xi′an Municipal Center for Disease Control and Prevention,Xi′an 710054,China;2nd Department of Infectious Diseases,Xi'an Children’s Hospital,Xi’an 710000,China;Maternal and Child Health Care Hospital of Huyi District,Xi′an 710300,China)

机构地区：[1]西安市疾病预防控制中心病毒科,710054 [2]西安市儿童医院感染二科,710000 [3]西安市鄠邑区妇幼保健院,710300

出　　处：《中华实验和临床病毒学杂志》2019年第5期478-481,共4页Chinese Journal of Experimental and Clinical Virology

基　　金：陕西省社会发展科技攻关项目(2016SF-230)。

摘　　要：目的分析西安市疱疹性咽峡炎的流行特征和病原感染情况,为防控疱疹性咽峡炎提供科学依据。方法收集西安市哨点医院上报的疱疹性咽峡炎病例,采用荧光定量PCR(Real-Time PCR)和巢式PCR扩增、测序对标本进行肠道病毒的检测和分型,用Excel和SPSS 18.0软件进行统计学分析。结果2016年西安市哨点医院共报告疱疹性咽峡炎病例421例,男女性别比为1.54∶1,患儿年龄范围为3个月~13岁,其中3岁以下婴幼儿占所有患者的90.50%,4~10月份病例占总发病数的87.17%,6月份报告病例数最多(23.75%,100/421)。152份标本中检出肠道病毒阳性108例,阳性率为71.05%,共检测出8种肠道病毒,包括肠道病毒71型(Enterovirus A71,EV-A71)、柯萨奇病毒A组4型、5型、6型、10型、12型、16型(Coxsackievirus A,CV-A)和柯萨奇病毒B组3型(Coxsackievirus B,CV-B),其中CV-A10和CV-A6的构成比分别为23.15%(25/108)和6.48%(7/108)。结论2016年西安市疱疹性咽颊炎6月份病例最多,3岁以下男性儿童为主,明确病原中以CV-A6和CV-A10多见。Objective To analyze the epidemiological characteristics and etiologic agent of herpangina in Xi’an in 2016.Methods Herpangina epidemiological data and random stool samples were collected from two sentinel hospitals.The data were statistically analyzed with Excel and SPSS 18.0 and samples were detected and enteroviruses were genotyped using real-time PCR and RT-snPCR.Results Totally 421 cases were reported and the male-to-female ratio was 1.54∶1,age ranged from 3 month to 13 years,and 90.50%were under three years of age.Herpangina showed semiannual peaks in April to October,of which the highest was in June(23.75%,100/421).Lab result showed that 71.05%were EV positive out of 152 samples,and further genotyping indicated 60 were non-typable,and other 48 comprised of eight serotypes of EV including EV-A71,CV-A4,CV-A5,CV-A6(6.48%),CV-A10(23.15%),CV-A12,CV-A16 and CV-B3.Conclusions Male children under 3 years of age were the main population and herpangina cases were most frequently reported in June in Xi’an in 2016.CV-A6 and CV-A10 were more frequently detected in the typable ones.

关 键 词：疱疹性咽峡炎 流行特征 肠道病毒 病原学构成 

分 类 号：R72[医药卫生—儿科]