2010—2018年德州市手足口病病原学特征分析  

Etiological characteristics of hand,foot and mouth disease in Dezhou city from 2010 to 2018

作　　者：王国强[1] 董健[1] 曹静[1] 杨卫红[2] 王冬梅[2] Wang Guoqiang;Dong Jian;Cao Jing;Yang Weihong;Wang Dongmei(Department of Laboratory,Dezhou Center for Disease Control and Prevention,Dezhou 253016,China;Department of Acute Infectious Diseases Control,Dezhou Center for Disease Control and Prevention,Dezhou 253016,China)

机构地区：[1]德州市疾病预防控制中心检验科,253016 [2]德州市疾病预防控制中心传染病防治科,253016

出　　处：《中华实验和临床病毒学杂志》2019年第5期485-488,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的分析德州市2010—2018年手足口病(hand,foot and mouth disease,HFMD)病原学特征,为HFMD防控提供科学依据。方法收集德州市2010—2018年各县市区临床诊断的HFMD病例粪便标本5186份,采用Real-time RT-PCR法进行肠道病毒(enterovirus,EV)核酸检测,分析其病原变化特征。结果2010—2018年德州市共检测HFMD病例标本5186份,总阳性率71.75%,其中EV-A711357例(26.17%)、CV-A16874例(16.85%),其他肠道病毒1490例(28.73%)。各月份总体检出率有显著性差异,6~8月份为检出率高峰期;不同年份的各型别优势毒株交替流行。重症病例和聚集性病例以EV-A71型为优势血清型,实验室确证病例以5岁以下幼儿为主(占96.25%)。结论德州市2010—2018年HFMD病例呈现明显季节性分布及特定人群高发。应加强病原学监测,在高发季节针对高危人群重点防控。Objective To understand the etiological characteristics of hand,foot and mouth diseases(HFMD)in Dezhou city from 2010 to 2018,and to provide laboratory evidence for its prevention and control.Methods A total of 5186 fecal specimens were collected from patients with HFMD.Real-time RT-PCR was used to detect enterovirus(EV)and analyze its pathogenic characteristics.Results From 2010 to 2018,5186 samples of HFMD cases were detected in Dezhou,with a total positive rate of 71.75%,including 1357 cases of EV-A71(26.17%),874 cases of CV-A16(16.85%)and 1490 cases of other Enteroviruses(28.73%).There were significant differences in the overall detection rate in each month.The peak period of detection rate was from June to August.The dominant virus strains with different types appeared dynamically in different years.EV-A71 was the predominant serotype in severe and aggregated cases.Laboratory confirmed cases were mainly children under 5 years old(96.25%).Conclusions From 2010 to 2018,the pathogen of HFMD in Dezhou city showed a dynamic change,with obvious seasonal distribution of cases and high incidence of specific population.Etiological surveillance should be strengthened to focus on prevention and control of high-risk population in high-risk season.

关 键 词：手足口病 肠道病毒 病原学分析 

分 类 号：R72[医药卫生—儿科]