共轭亚油酸的生物学功能及其在动物生产中的应用  

Biological Function of Conjugated Linoleic Acid and Its Application in Animal Production

作　　者：杨媚 马杰[1] 杨泰[1] 闫昭明 陈清华[1] YANG Mei;MA Jie;YANG Tai;YAN Zhaoming;CHEN Qinghua(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学动物科学技术学院

出　　处：《中国畜牧兽医》2019年第11期3216-3224,共9页China Animal Husbandry & Veterinary Medicine

基　　金：长沙市科技计划项目(kq1801017)

摘　　要：共轭亚油酸(CLA)作为一种天然的新型功能性脂肪酸,具有抗高血压、抗癌、抗糖尿病等生物学特性,其发挥不同作用的主要活性异构体不同。近年来,随着CLA人工合成成本的降低及动物营养领域研究的深入,发现CLA既可抑制促炎因子的表达和产生,促进抑炎因子的产生,达到抗炎的效果;又可调控淋巴细胞的增殖和分化、巨噬细胞的活性、促进抗体合成,调节机体体液免疫和细胞免疫,进而增强动物免疫力;CLA还可调节多种核转录因子的表达,影响脂肪酸的摄取和氧化及脂质的合成代谢,从而降低体脂沉积,提高肌内脂肪含量,改变脂肪酸组成,改善肉品质等。因此CLA在畜牧业生产中具有潜在的应用价值和广阔的市场前景。作者主要介绍了CLA在抗炎、免疫功能、脂质代谢和抗氧化等方面的作用,综述了CLA的生物学功能及其在动物生产上的应用研究进展。此外,还探讨了CLA作为饲料添加剂,其合成纯度,在不同种类动物、不同年龄阶段的最适添加量、饲喂方式等问题,旨在为其在动物生产中的合理应用提供理论参考。As a natural new functional fatty acid,conjugated linoleic acid(CLA)has anti-hypertensive,anti-cancer,anti-diabetic and other biological properties,and its main active isomers play different roles.In recent years,with the decrease of CLA artificial synthesis cost and the deep researches in the field of animal nutrition,it was found that CLA can inhibit the expression and production of pro-inflammatory factors,promote the production of anti-inflammatory factors,and achieve anti-inflammatory effects,it can also regulate lymphocyte proliferation and differentiation,macrophage activity,promote antibody synthesis,regulate humoral immunity and cellular immunity,thereby enhancing animal immunity.CLA can also regulate the expression of a variety of nuclear transcription factors,affect fatty acid uptake and oxidation,as well as lipid anabolism,thereby reducing body fat deposition,increasing intramuscular fat content,changing fatty acid composition,and improving meat quality.Therefore,CLA has potential application value and broad market prospects in animal husbandry production.The article mainly introduced the roles of CLA in anti-inflammatory,immune function,lipid metabolism and anti-oxidation,and reviewed the biological functions of CLA and its application researches in animal production.In addition,CLA was also discussed as a feed additive,including its synthetic purity,optimal addition amount in different types of animals,different ages,feeding methods,in order to provide a theoretical reference for its rational application in animal production.

关 键 词：共轭亚油酸(CLA) 抗炎 免疫调节 脂质代谢 抗氧化 

分 类 号：S816.7[农业科学—饲料科学]