NF-E2相关因子2通路对线粒体功能的调控作用  

Regulatory role of NF-E2-related factor 2 pathway in mitochondrial function

作　　者：尹圆圆 彭辉 邵军波 彭双清 皮静波[2] 郭家彬 YIN Yuan-yuan;PENG Hui;SHAO Jun-bo;PENG Shuang-qing;PI Jing-bo;GUO Jia-bin(Evaluation and Research Centre for Toxicology,Center of Disease Control and Prevention,PLA,Beijing 100071,China;School of Public Health,China Medical University,Shenyang 110122,China)

机构地区：[1]中国人民解放军疾病预防控制中心,北京100071 [2]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《中国药理学与毒理学杂志》2019年第7期542-549,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：国家重点研发计划课题(2018YFC1602602);国家自然科学基金(81430090);国家自然科学基金(81903732);北京市科技新星项目(Z171100001117103)~~

摘　　要：NF-E2相关因子2(Nrf2)是CNC碱性亮氨酸拉链家族成员之一,在维持细胞氧化-还原稳态、调节细胞能量代谢、炎症反应、凋亡和自噬等细胞反应中发挥着重要作用。线粒体是细胞合成ATP的主要场所,也是细胞内活性氧自由基的主要来源之一。近年来,越来越多的研究提示,Nrf2通路可通过多种方式或机制调控线粒体功能,进而调节细胞对外源性物质的反应与有害结局,包括调节活性氧自由基水平、抑制线粒体膜电位下降、促进ATP合成、保护线粒体脂肪酸氧化和氧化磷酸化以及线粒体生物合成等,同时也可调节线粒体完整性和线粒体自噬。此外,Nrf2通路对毒物诱导的线粒体兴奋效应也具有重要影响。本文综述了近年来Nrf2通路对线粒体功能的调控作用及其机制。NF-E2-related factor 2(Nrf2)is a member of the CNC basic leucine zipper(b-ZIP)family,which plays a key role in maintaining cell redox homeostasis,regulating energy metabolism,inflammatory response,apoptosis,and autophagy.Mitochondria are the main sites for ATP synthesis,and one of the main sources of reactive oxygen free radicals.Recently,increasing studies have suggested that Nrf2 pathway may play a critical role in regulation of mitochondrial function in various ways and involving multiple mechanisms,thus regulating cellular responses and adverse outcomes to endogenous stimuli.These include regulation of reactive oxygen species levels,inhibition of mitochondrial membrane poten tial decline,promotion of ATP synthesis,protection of mitochondrial fatty acid oxidation and oxidative phosphorylation,mitochondrial biogenesis,and maintenance of mitochondrial integrity as well as mito chondrial autophagy.In addition,Nrf2 pathway also plays an important role in regulation of toxicant induced mitohormesis.This review summarizes recent research progress in the regulation of mitochondri al function by Nrf2 pathway and its mechanism.

关 键 词：NF-E2相关因子2 线粒体 能量代谢 氧化应激 

分 类 号：R963[医药卫生—微生物与生化药学]