南通市启东和海门籍肝癌住院患者生存率分析  

Survival of liver cancer inpatients from Qidong and Haimen region of Jiangsu province

作　　者：陈建国[1,2] 陈海珍[1] 朱健[2] 杨艳蕾[3] 张永辉[2] 黄培新[3] 陈永胜[2] 管云 冒小平[1] 施民新[1] 王高仁[1] CHEN Jian-guo;CHEN Hai-zhen;ZHU Jian(Tumor Hospital/Institute Affiliated to Nantong University,Nantong,Jiangsu Province 226361,China)

机构地区：[1]南通大学附属肿瘤医院/研究所,江苏南通226361 [2]启东肝癌防治研究所 [3]海门市疾病预防控制中心

出　　处：《中国公共卫生》2019年第11期1540-1543,共4页Chinese Journal of Public Health

基　　金：南通市科技局科技计划项目(qyz15017;CP22012005)

摘　　要：目的分析江苏省南通大学附属肿瘤医院2002-2014年启东和海门籍肝癌住院患者的生存率,为综合评估肝癌患者的预后提供参考依据。方法收集医院癌症登记系统2002年1月1日-2014年12月31日的启东和海门籍肝癌住院患者信息,采用主动与被动相结合的方法进行生存结局的随访,随访截止于2016年3月31日;采用寿命表法计算各年观察生存率,并比较性别、年龄和籍贯之间的差异。结果南通大学附属肿瘤医院2002-2014年共收治启东和海门籍肝癌患者486例,经随访共获得475例患者的癌症生存结局信息,随访率为97.74%;失访11例,失访率为2.26%。肝癌患者的1、3、5和10年观察生存率分别为35.16%、17.52%、11.69%和6.34%,其中男性分别为31.66%、14.54%、9.18%和3.17%,女性分别为48.96%、29.39%、21.94%和13.96%,女性肝癌患者生存率高于男性,差异有统计学意义(P=0.001);0~44、45~54、55~64、65~74和≥75岁肝癌患者的5年生存率分别为10.07%、12.48%、8.46%、19.01%和0,差异无统计学意义(P> 0.05);启东籍肝癌患者的5年生存率为14.62%,高于海门籍患者的10.31%,差异有统计学意义(P <0.001)。结论启东和海门籍肝癌住院患者的生存率具有女性高于男性、启东籍患者高于海门籍患者的特点,但不同年龄患者生存率无差异。Objective To analyze survival rate of liver cancer patients hospitalized between 2002 and 2014 in Tumor Hospital Affiliated to Nantong University and to provide evidences for comprehensive evaluation on liver cancer prognosis.Methods We extracted data on liver cancer inpatients from Qidong and Haimen region of Jiangsu province and hospitalized between January 1 st 2002 and December 31 st 2014 from Hospital Information System and adopted active and passive follow-up method to obtain information on survival status till March 31 st 2016 for all the inpatients recruited. Survival probability(observed survival, OS) was estimated using life-table method with SPSS 22, and differences in survival rates were analyzed by gender, age, and birthplace with Wilcoxon(Gehan) statistics. Results Survival information were collected from 475(97.74%) of all inpatients recruited and the 1-, 3-, 5-, and 10-year OS rate of the inpatients were 35.16%, 17.52%,11.69%, and 6.34%, respectively;the 1-, 3-, 5-, and 10-year OS rates of the female inpatients(48.96%, 29.39%, 21.94%, and13.96%) were significantly higher than those of the male inpatients(31.66%, 14.54%, 9.18%, and 3.17%)(P = 0.001). The 5-year OS rate of the inpatients aged 0 – 44, 45 – 54, 55 – 64, 65 – 74, and ≥ 75 years were 10.07%, 12.48%, 8.46%, 19.01%,and 0, respectively, with no significant difference(P > 0.05). The 5-year OS rate was 14.62% and 10.31% for the inpatients from Qidong and Haimen region, with a significant difference(P < 0.001). Conclusion Among liver cancer inpatients from Qidong and Haimen region of Jiangsu province, the observed survival rate is higher among females than among the males and the rate is higher among those from Qidong region than among those in Haimen region, but the rate does not significantly differ by age groups.

关 键 词：肝癌 住院患者 生存率分析 

分 类 号：R195.4[医药卫生—卫生统计学]